Persistent HIV RNA shedding in semen despite effective antiretroviral therapy

Prameet M. Sheth, Colin Kovacs, Kimdar S. Kemal, R. Brad Jones, Janet M. Raboud, Richard Pilon, Charles La Porte, Mario Ostrowski, Mona Loutfy, Harold Burger, Barbara Weiser, Rupert Kaul

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Effective antiretroviral therapy (ART) may reduce HIV sexual transmission by lowering genital HIV levels. A prospective study of men starting ART (n = 25) demonstrated rapid, substantial reductions in semen HIV RNA. However, despite an undetectable blood viral load, isolated semen HIV shedding was detected at more than one visit in 12 of 25 (48%) participants, with semen HIV RNA levels exceeding 5000 copies/ml in four of 25 (16%). Isolates were drug-sensitive, and this phenomenon was not associated with semen drug levels or regimen.

Original languageEnglish (US)
Pages (from-to)2050-2054
Number of pages5
JournalAIDS
Volume23
Issue number15
DOIs
StatePublished - Sep 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Sheth, P. M., Kovacs, C., Kemal, K. S., Jones, R. B., Raboud, J. M., Pilon, R., La Porte, C., Ostrowski, M., Loutfy, M., Burger, H., Weiser, B., & Kaul, R. (2009). Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. AIDS, 23(15), 2050-2054. https://doi.org/10.1097/QAD.0b013e3283303e04