Persistent HIV RNA shedding in semen despite effective antiretroviral therapy

Prameet M. Sheth, Colin Kovacs, Kimdar S. Kemal, R. Brad Jones, Janet M. Raboud, Richard Pilon, Charles La Porte, Mario Ostrowski, Mona Loutfy, Harold Burger, Barbara Weiser, Rupert Kaul

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Effective antiretroviral therapy (ART) may reduce HIV sexual transmission by lowering genital HIV levels. A prospective study of men starting ART (n = 25) demonstrated rapid, substantial reductions in semen HIV RNA. However, despite an undetectable blood viral load, isolated semen HIV shedding was detected at more than one visit in 12 of 25 (48%) participants, with semen HIV RNA levels exceeding 5000 copies/ml in four of 25 (16%). Isolates were drug-sensitive, and this phenomenon was not associated with semen drug levels or regimen.

Original languageEnglish (US)
Pages (from-to)2050-2054
Number of pages5
JournalAIDS
Volume23
Issue number15
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Semen
HIV
RNA
Therapeutics
Viral Load
Pharmaceutical Preparations
Prospective Studies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Sheth, P. M., Kovacs, C., Kemal, K. S., Jones, R. B., Raboud, J. M., Pilon, R., ... Kaul, R. (2009). Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. AIDS, 23(15), 2050-2054. https://doi.org/10.1097/QAD.0b013e3283303e04

Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. / Sheth, Prameet M.; Kovacs, Colin; Kemal, Kimdar S.; Jones, R. Brad; Raboud, Janet M.; Pilon, Richard; La Porte, Charles; Ostrowski, Mario; Loutfy, Mona; Burger, Harold; Weiser, Barbara; Kaul, Rupert.

In: AIDS, Vol. 23, No. 15, 09.2009, p. 2050-2054.

Research output: Contribution to journalArticle

Sheth, PM, Kovacs, C, Kemal, KS, Jones, RB, Raboud, JM, Pilon, R, La Porte, C, Ostrowski, M, Loutfy, M, Burger, H, Weiser, B & Kaul, R 2009, 'Persistent HIV RNA shedding in semen despite effective antiretroviral therapy', AIDS, vol. 23, no. 15, pp. 2050-2054. https://doi.org/10.1097/QAD.0b013e3283303e04
Sheth PM, Kovacs C, Kemal KS, Jones RB, Raboud JM, Pilon R et al. Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. AIDS. 2009 Sep;23(15):2050-2054. https://doi.org/10.1097/QAD.0b013e3283303e04
Sheth, Prameet M. ; Kovacs, Colin ; Kemal, Kimdar S. ; Jones, R. Brad ; Raboud, Janet M. ; Pilon, Richard ; La Porte, Charles ; Ostrowski, Mario ; Loutfy, Mona ; Burger, Harold ; Weiser, Barbara ; Kaul, Rupert. / Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. In: AIDS. 2009 ; Vol. 23, No. 15. pp. 2050-2054.
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