Persistent CT nephrograms following cardiac catheterisation and intervention: Initial observations

Richard W Katzberg, Wayne L. Monsky, Nicolas D. Prionas, Vishal Sidhar, Jeffrey Southard, Janine Carlson, John M Boone, Tzu Chun Lin, Chin-Shang Li

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives To describe persistent nephrographic patterns detected by unenhanced renal CT at 24 h after cardiac catheterisation and intervention. Methods This prospective study was Health Insurance Portability and Accountability Act-compliant and institutional review board approved. Twenty-nine patients (20 men, nine women; average age 63.27 and range 41-85 years) agreed to undergo unenhanced dual-energy computed tomography (CT) limited to their kidneys at 24 h after cardiac catheterisation. CT attenuation values (Hounsfield units) were made from the cortical and medullary regions and single kidney total parenchymal iodine values (milligrams) were measured. Spearman's rank correlation coefficient and a two-sided Fisher's exact test were used in the statistics. Results Focal nephrograms were observed in at least one kidney (range, one to five regions per kidney) in 10/29 (34%) of patients and bilateral global nephrograms in 13/29 (45%) of patients. Focal nephrograms correlated with cardiac catheterisation fluoroscopic time (r=0.48; P= 0.0087). For global nephrograms, the total iodine content of right and left kidneys correlated with fluoroscopic time (r=0.79 and 0.76; P < 0.0001, respectively) and the amount of contrast material (CM) used (r=0.77 and r=0.74; P < 0.0001, respectively). Conclusion Persistent focal and global nephrograms occur commonly as assessed by non-contrast CT at 24 h post cardiac catheterisation and our observations suggest they could be related to procedural factors.

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalInsights into Imaging
Volume3
Issue number1
DOIs
StatePublished - 2012

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Cardiac Catheterization
Tomography
Kidney
Iodine
Health Insurance Portability and Accountability Act
Research Ethics Committees
Nonparametric Statistics
Contrast Media
Prospective Studies

Keywords

  • Cardiac
  • Contrast media
  • CT
  • Interventional
  • Urogenital

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Persistent CT nephrograms following cardiac catheterisation and intervention : Initial observations. / Katzberg, Richard W; Monsky, Wayne L.; Prionas, Nicolas D.; Sidhar, Vishal; Southard, Jeffrey; Carlson, Janine; Boone, John M; Lin, Tzu Chun; Li, Chin-Shang.

In: Insights into Imaging, Vol. 3, No. 1, 2012, p. 49-60.

Research output: Contribution to journalArticle

Katzberg, Richard W ; Monsky, Wayne L. ; Prionas, Nicolas D. ; Sidhar, Vishal ; Southard, Jeffrey ; Carlson, Janine ; Boone, John M ; Lin, Tzu Chun ; Li, Chin-Shang. / Persistent CT nephrograms following cardiac catheterisation and intervention : Initial observations. In: Insights into Imaging. 2012 ; Vol. 3, No. 1. pp. 49-60.
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abstract = "Objectives To describe persistent nephrographic patterns detected by unenhanced renal CT at 24 h after cardiac catheterisation and intervention. Methods This prospective study was Health Insurance Portability and Accountability Act-compliant and institutional review board approved. Twenty-nine patients (20 men, nine women; average age 63.27 and range 41-85 years) agreed to undergo unenhanced dual-energy computed tomography (CT) limited to their kidneys at 24 h after cardiac catheterisation. CT attenuation values (Hounsfield units) were made from the cortical and medullary regions and single kidney total parenchymal iodine values (milligrams) were measured. Spearman's rank correlation coefficient and a two-sided Fisher's exact test were used in the statistics. Results Focal nephrograms were observed in at least one kidney (range, one to five regions per kidney) in 10/29 (34{\%}) of patients and bilateral global nephrograms in 13/29 (45{\%}) of patients. Focal nephrograms correlated with cardiac catheterisation fluoroscopic time (r=0.48; P= 0.0087). For global nephrograms, the total iodine content of right and left kidneys correlated with fluoroscopic time (r=0.79 and 0.76; P < 0.0001, respectively) and the amount of contrast material (CM) used (r=0.77 and r=0.74; P < 0.0001, respectively). Conclusion Persistent focal and global nephrograms occur commonly as assessed by non-contrast CT at 24 h post cardiac catheterisation and our observations suggest they could be related to procedural factors.",
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AU - Southard, Jeffrey

AU - Carlson, Janine

AU - Boone, John M

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N2 - Objectives To describe persistent nephrographic patterns detected by unenhanced renal CT at 24 h after cardiac catheterisation and intervention. Methods This prospective study was Health Insurance Portability and Accountability Act-compliant and institutional review board approved. Twenty-nine patients (20 men, nine women; average age 63.27 and range 41-85 years) agreed to undergo unenhanced dual-energy computed tomography (CT) limited to their kidneys at 24 h after cardiac catheterisation. CT attenuation values (Hounsfield units) were made from the cortical and medullary regions and single kidney total parenchymal iodine values (milligrams) were measured. Spearman's rank correlation coefficient and a two-sided Fisher's exact test were used in the statistics. Results Focal nephrograms were observed in at least one kidney (range, one to five regions per kidney) in 10/29 (34%) of patients and bilateral global nephrograms in 13/29 (45%) of patients. Focal nephrograms correlated with cardiac catheterisation fluoroscopic time (r=0.48; P= 0.0087). For global nephrograms, the total iodine content of right and left kidneys correlated with fluoroscopic time (r=0.79 and 0.76; P < 0.0001, respectively) and the amount of contrast material (CM) used (r=0.77 and r=0.74; P < 0.0001, respectively). Conclusion Persistent focal and global nephrograms occur commonly as assessed by non-contrast CT at 24 h post cardiac catheterisation and our observations suggest they could be related to procedural factors.

AB - Objectives To describe persistent nephrographic patterns detected by unenhanced renal CT at 24 h after cardiac catheterisation and intervention. Methods This prospective study was Health Insurance Portability and Accountability Act-compliant and institutional review board approved. Twenty-nine patients (20 men, nine women; average age 63.27 and range 41-85 years) agreed to undergo unenhanced dual-energy computed tomography (CT) limited to their kidneys at 24 h after cardiac catheterisation. CT attenuation values (Hounsfield units) were made from the cortical and medullary regions and single kidney total parenchymal iodine values (milligrams) were measured. Spearman's rank correlation coefficient and a two-sided Fisher's exact test were used in the statistics. Results Focal nephrograms were observed in at least one kidney (range, one to five regions per kidney) in 10/29 (34%) of patients and bilateral global nephrograms in 13/29 (45%) of patients. Focal nephrograms correlated with cardiac catheterisation fluoroscopic time (r=0.48; P= 0.0087). For global nephrograms, the total iodine content of right and left kidneys correlated with fluoroscopic time (r=0.79 and 0.76; P < 0.0001, respectively) and the amount of contrast material (CM) used (r=0.77 and r=0.74; P < 0.0001, respectively). Conclusion Persistent focal and global nephrograms occur commonly as assessed by non-contrast CT at 24 h post cardiac catheterisation and our observations suggest they could be related to procedural factors.

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