Peroxisomal localization of serine: pyruvate aminotransferase in human liver.

T. Noguchi, Yoshikazu Takada

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The distribution of L-serine:pyruvate aminotransferase (EC 2.6.1.51) in human liver was examined by centrifugation in a sucrose density gradient. The enzyme was located only in the peroxisomes and in the soluble fraction. The peroxisomal and soluble enzymes were highly purified and characterized. The two enzyme preparations had nearly identical properties, suggesting that the soluble enzyme is from broken peroxisomes. The two enzyme preparations showed different properties from rat liver serine:pyruvate aminotransferase (Noguchi, T., Okuno, E., and Kido, R. (1976) Biochem. J. 159, 607-613).

Original languageEnglish (US)
Pages (from-to)7598-7600
Number of pages3
JournalJournal of Biological Chemistry
Volume253
Issue number21
StatePublished - Nov 10 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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