Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva

Thomas F. Lanchoney, Randolph B. Cohen, David M Rocke, Michael A. Zasloff, Frederick S. Kaplan

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

In patients who have fibrodysplasia ossificans progressiva, routine childhood diphtheria-tetanus-pertussis immunizations administered by intramuscular injection caused a significant risk of permanent heterotopic ossification at the site of injection ( p <10 \-8 ), whereas measles-mumps-rubella immunizations administered by subcutaneous injection posed no significant risk. Intramuscular injections should be avoided, if possible, once a diagnosis of fibrodysplasia ossificans progressiva has been established. (J P EDIATR 1995;126:762-4).

Original languageEnglish (US)
Pages (from-to)762-764
Number of pages3
JournalThe Journal of Pediatrics
Volume126
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva'. Together they form a unique fingerprint.

  • Cite this