Peritoneal dialysis outcomes in a modern cohort of overweight patients

Shubha Ananthakrishnan, Nigar Sekercioglu, Rosilene M. Elias, Joseph Kim, Dimitrios Oreopoulos, Maggie Chu, Joanne M. Bargman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The incidence of obesity is increasing both in the general population and in incident dialysis patients. While there is evidence that being overweight is associated with good outcomes in hemodialysis, the evidence in peritoneal dialysis (PD) patients is not very clear. We studied a modern cohort of PD patients to examine outcomes in large patients. Methods: Forty-three patients who started PD, who weighed more than 90 kg at dialysis initiation, between January/2000 and June/2010 were matched with 43 control patients who weighed less than 90 kg. Detailed review of the charts was undertaken. Results: The mean weight and body mass index of the wt < 90 kg group were 69.3 ± 11.3 kg and 25.0 ± 3.9 kg/m2. The number of peritonitis episodes per year was 0.33 ± 0.6 (wt < 90 kg) and 0.82 ± 1.7 (wt ≥ 90 kg) (p = 0.26). The median time to first peritonitis showed a trend toward earlier peritonitis in larger patients [9.5 (4.3, 27) months in wt ≥ 90 kg, 19.1(7.9, 30.8) months in wt < 90 kg] but did not reach statistical significance (p = 0.12). Surprisingly, hernias and leaks were more common in the weight <90 kg group (44 vs. 18.6 % p = 0.02). There was no difference in total number of hospitalizations or the number of days hospitalized. Kaplan-Meier analysis of survival on PD showed no differences between the two groups (logrank p = 0.99). Cox regression analysis using age, race, cause of ESRD due to diabetes and Charlson comorbidity index as the covariates did not show weight to be associated with survival on PD. Conclusions: Large patients tend to do just as well on PD, with survival on PD being no different compared to individuals with lower weight and body mass index.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalInternational Urology and Nephrology
Volume46
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Fingerprint

Peritoneal Dialysis
Peritonitis
Weights and Measures
Survival
Dialysis
Body Mass Index
Kaplan-Meier Estimate
Hernia
Chronic Kidney Failure
Renal Dialysis
Comorbidity
Hospitalization
Obesity
Regression Analysis
Incidence
Population

Keywords

  • Obesity
  • Peritoneal dialysis
  • Peritonitis

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Ananthakrishnan, S., Sekercioglu, N., Elias, R. M., Kim, J., Oreopoulos, D., Chu, M., & Bargman, J. M. (2014). Peritoneal dialysis outcomes in a modern cohort of overweight patients. International Urology and Nephrology, 46(1), 183-189. https://doi.org/10.1007/s11255-013-0472-5

Peritoneal dialysis outcomes in a modern cohort of overweight patients. / Ananthakrishnan, Shubha; Sekercioglu, Nigar; Elias, Rosilene M.; Kim, Joseph; Oreopoulos, Dimitrios; Chu, Maggie; Bargman, Joanne M.

In: International Urology and Nephrology, Vol. 46, No. 1, 01.2014, p. 183-189.

Research output: Contribution to journalArticle

Ananthakrishnan, S, Sekercioglu, N, Elias, RM, Kim, J, Oreopoulos, D, Chu, M & Bargman, JM 2014, 'Peritoneal dialysis outcomes in a modern cohort of overweight patients', International Urology and Nephrology, vol. 46, no. 1, pp. 183-189. https://doi.org/10.1007/s11255-013-0472-5
Ananthakrishnan, Shubha ; Sekercioglu, Nigar ; Elias, Rosilene M. ; Kim, Joseph ; Oreopoulos, Dimitrios ; Chu, Maggie ; Bargman, Joanne M. / Peritoneal dialysis outcomes in a modern cohort of overweight patients. In: International Urology and Nephrology. 2014 ; Vol. 46, No. 1. pp. 183-189.
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