Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls

Nancy A. Mervish, Susan L. Teitelbaum, Ashley Pajak, Gayle C. Windham, Susan M. Pinney, Lawrence H. Kushi, Frank M. Biro, Mary S. Wolff

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BackgroundDietary phytoestrogens may alter hormonal activity in childhood. Flavonols and lignans are the most prevalent phytoestrogens in the Western diet. We examined whether higher intake of flavonols and lignans was associated with later age at menarche in a prospective study of young girls.MethodsIn all, 1,044 girls aged 6-8 years (mean 7.3 years) with two to four 24-h dietary recalls during their baseline year were followed up for 11 years until the attainment of menarche in the Breast Cancer and Environment Research Project (BCERP). Associations of age at menarche with quintiles of phytoestrogens were assessed using hazard ratios (HR) and 95% confidence intervals (CIs) from Cox proportional hazards models, controlling for body mass index and other covariates.ResultsThe highest quintile of flavonol intake was associated with a later age at menarche, compared with the lowest quintile (adjusted HR: 0.80, 95% CI: (0.66-1.00). For lignans, there was a later age in overweight girls (HR: 0.56, 95% CI=0.40-0.80).ConclusionThese dietary bioactives may reflect a healthy diet, and foods high in phytoestrogens may influence the timing of menarche.

Original languageEnglish (US)
Pages (from-to)201-208
Number of pages8
JournalPediatric Research
Volume82
Issue number2
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

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Lignans
Menarche
Phytoestrogens
Flavonols
Confidence Intervals
Proportional Hazards Models
Body Mass Index
3-hydroxyflavone
Prospective Studies
Breast Neoplasms
Food
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mervish, N. A., Teitelbaum, S. L., Pajak, A., Windham, G. C., Pinney, S. M., Kushi, L. H., ... Wolff, M. S. (2017). Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls. Pediatric Research, 82(2), 201-208. https://doi.org/10.1038/pr.2017.34

Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls. / Mervish, Nancy A.; Teitelbaum, Susan L.; Pajak, Ashley; Windham, Gayle C.; Pinney, Susan M.; Kushi, Lawrence H.; Biro, Frank M.; Wolff, Mary S.

In: Pediatric Research, Vol. 82, No. 2, 01.08.2017, p. 201-208.

Research output: Contribution to journalArticle

Mervish, NA, Teitelbaum, SL, Pajak, A, Windham, GC, Pinney, SM, Kushi, LH, Biro, FM & Wolff, MS 2017, 'Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls', Pediatric Research, vol. 82, no. 2, pp. 201-208. https://doi.org/10.1038/pr.2017.34
Mervish NA, Teitelbaum SL, Pajak A, Windham GC, Pinney SM, Kushi LH et al. Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls. Pediatric Research. 2017 Aug 1;82(2):201-208. https://doi.org/10.1038/pr.2017.34
Mervish, Nancy A. ; Teitelbaum, Susan L. ; Pajak, Ashley ; Windham, Gayle C. ; Pinney, Susan M. ; Kushi, Lawrence H. ; Biro, Frank M. ; Wolff, Mary S. / Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls. In: Pediatric Research. 2017 ; Vol. 82, No. 2. pp. 201-208.
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