Peripheral survival of naïve CD8+ T cells

Ian Elliott Brown, M. Mashayekhi, M. Markiewicz, M. L. Alegre, T. F. Gajewski

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Maintenance of a sufficient population of naïve CD8+ T cells in the peripheral lymphoid compartment is critical for immunocompetence. Peripheral T cell number is a function of T cell generation, survival, and death. Homeostasis, a critical balance between survival and death, must exist to prevent either lymphopenia or lymphocytosis. In the current review, we discuss known requirements for the survival of naïve peripheral CD8+ T cells as well as mechanisms of death when survival signals are lost. We also discuss associations between survival and homeostasis-driven proliferation, and highlight the gaps in our knowledge of these critical processes.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalApoptosis
Volume10
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

T-cells
T-Lymphocytes
Homeostasis
Immunocompetence
Lymphocytosis
Lymphopenia
Cell Survival
Cell Death
Cell Count
Maintenance
Population

Keywords

  • CD8
  • Naive
  • Peripheral
  • Survival
  • T cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Brown, I. E., Mashayekhi, M., Markiewicz, M., Alegre, M. L., & Gajewski, T. F. (2005). Peripheral survival of naïve CD8+ T cells. Apoptosis, 10(1), 5-11. https://doi.org/10.1007/s10495-005-6056-9

Peripheral survival of naïve CD8+ T cells. / Brown, Ian Elliott; Mashayekhi, M.; Markiewicz, M.; Alegre, M. L.; Gajewski, T. F.

In: Apoptosis, Vol. 10, No. 1, 01.2005, p. 5-11.

Research output: Contribution to journalReview article

Brown, IE, Mashayekhi, M, Markiewicz, M, Alegre, ML & Gajewski, TF 2005, 'Peripheral survival of naïve CD8+ T cells', Apoptosis, vol. 10, no. 1, pp. 5-11. https://doi.org/10.1007/s10495-005-6056-9
Brown IE, Mashayekhi M, Markiewicz M, Alegre ML, Gajewski TF. Peripheral survival of naïve CD8+ T cells. Apoptosis. 2005 Jan;10(1):5-11. https://doi.org/10.1007/s10495-005-6056-9
Brown, Ian Elliott ; Mashayekhi, M. ; Markiewicz, M. ; Alegre, M. L. ; Gajewski, T. F. / Peripheral survival of naïve CD8+ T cells. In: Apoptosis. 2005 ; Vol. 10, No. 1. pp. 5-11.
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