Peripheral survival of naïve CD8+ T cells

Ian Elliott Brown, M. Mashayekhi, M. Markiewicz, M. L. Alegre, T. F. Gajewski

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Maintenance of a sufficient population of naïve CD8+ T cells in the peripheral lymphoid compartment is critical for immunocompetence. Peripheral T cell number is a function of T cell generation, survival, and death. Homeostasis, a critical balance between survival and death, must exist to prevent either lymphopenia or lymphocytosis. In the current review, we discuss known requirements for the survival of naïve peripheral CD8+ T cells as well as mechanisms of death when survival signals are lost. We also discuss associations between survival and homeostasis-driven proliferation, and highlight the gaps in our knowledge of these critical processes.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
Issue number1
StatePublished - Jan 2005
Externally publishedYes


  • CD8
  • Naive
  • Peripheral
  • Survival
  • T cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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