Peripheral neuropathies of childhood

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This article has provided a brief overview of the most common inherited and acquired peripheral nerve diseases encountered in childhood. The diagnostic approach of peripheral neuropathies in children often relies on some combination of careful history taking, physical examination findings, a careful determination of family history, electrodiagnostic studies, molecular genetic studies, sural nerve biopsy, and occasionally metabolic laboratory studies. Although pediatric mononeuropathies may have different causes than those observed in adults, the clinical presentations, diagnostic evaluation, and management of mononeuropathies are frequently similar in adults and children. Encouraging progress is being made in the management of acute inflammatory demyelinating polyneuropathy (AIDP), which is the most common acquired neuropathy of childhood. Rapid advances in molecular genetics over the past decade have had a significant impact on our diagnostic approach to hereditary motor sensory neuropathy in particular. In the future it is likely that the sequencing of genes, characterization of protein structure and function, and further elucidation of pathophysiology will have significant impacts on the treatment of many inherited peripheral neuropathies of childhood.

Original languageEnglish (US)
Pages (from-to)473-490
Number of pages18
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume12
Issue number2
StatePublished - 2001

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Mononeuropathies
Peripheral Nervous System Diseases
Molecular Biology
Hereditary Sensory and Motor Neuropathy
Sural Nerve
Guillain-Barre Syndrome
Physical Examination
Pediatrics
Biopsy
Proteins
Therapeutics
Inherited Peripheral Neuropathy

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Peripheral neuropathies of childhood. / McDonald, Craig M.

In: Physical Medicine and Rehabilitation Clinics of North America, Vol. 12, No. 2, 2001, p. 473-490.

Research output: Contribution to journalArticle

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