Abstract
Experimental allergic neuritis (EAN) was induced in Lewis rats by injection of 'SP26', a peptide homologous to amino acids 53-78 of bovine myelin P2 protein, in complete Freund's adjuvant. The rats developed signs of EAN which began on day 14, were maximal on day 18, and had subsided by day 30. RNA content of cauda equina and sciatic nerves increased more than 2-fold at the height of EAN. Expression of myelin Po and PI mRNAs did not fall during EAN, nor rise during recovery. Fc γ mRNA, which encodes Fc γ RIII, an immunogloubulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 43-49 |
| Number of pages | 7 |
| Journal | Journal of Neuroimmunology |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Demyelination
- Experimental allergic neuritis
- Immunoglobulin-binding protein
- Myelin protein
- P2 basic protein
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology
Cite this
Peripheral nervous system (PNS) expression of mRNAs encoding myelin proteins and Fc γ RIII during experimental allergic neuritis. / Conti, Giancarlo; Vedeler, Christian; Bannerman, Peter; Rostami, Abdolmohammad; Pleasure, David E.
In: Journal of Neuroimmunology, Vol. 41, No. 1, 1992, p. 43-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peripheral nervous system (PNS) expression of mRNAs encoding myelin proteins and Fc γ RIII during experimental allergic neuritis
AU - Conti, Giancarlo
AU - Vedeler, Christian
AU - Bannerman, Peter
AU - Rostami, Abdolmohammad
AU - Pleasure, David E
PY - 1992
Y1 - 1992
N2 - Experimental allergic neuritis (EAN) was induced in Lewis rats by injection of 'SP26', a peptide homologous to amino acids 53-78 of bovine myelin P2 protein, in complete Freund's adjuvant. The rats developed signs of EAN which began on day 14, were maximal on day 18, and had subsided by day 30. RNA content of cauda equina and sciatic nerves increased more than 2-fold at the height of EAN. Expression of myelin Po and PI mRNAs did not fall during EAN, nor rise during recovery. Fc γ mRNA, which encodes Fc γ RIII, an immunogloubulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness.
AB - Experimental allergic neuritis (EAN) was induced in Lewis rats by injection of 'SP26', a peptide homologous to amino acids 53-78 of bovine myelin P2 protein, in complete Freund's adjuvant. The rats developed signs of EAN which began on day 14, were maximal on day 18, and had subsided by day 30. RNA content of cauda equina and sciatic nerves increased more than 2-fold at the height of EAN. Expression of myelin Po and PI mRNAs did not fall during EAN, nor rise during recovery. Fc γ mRNA, which encodes Fc γ RIII, an immunogloubulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness.
KW - Demyelination
KW - Experimental allergic neuritis
KW - Immunoglobulin-binding protein
KW - Myelin protein
KW - P2 basic protein
UR - http://www.scopus.com/inward/record.url?scp=0026452829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026452829&partnerID=8YFLogxK
U2 - 10.1016/0165-5728(92)90194-P
DO - 10.1016/0165-5728(92)90194-P
M3 - Article
C2 - 1281167
AN - SCOPUS:0026452829
VL - 41
SP - 43
EP - 49
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1
ER -