Peripheral artery disease and genetics: Is there a cause-and-effect relationship?

Yung-wei Chi, Michael R. Jaff

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Peripheral artery disease (PAD) is a major health problem worldwide, affecting millions of patients. Although cardiovascular risk factors, such as diabetes, tobacco use, hypertension, and hypercholesterolemia have been associated with the development of PAD, the possible existence of an inherited genetic predisposition to PAD has been investigated in numerous familial aggregation studies. A link between genetics and PAD may open new avenues for the prevention of this morbid and mortal disorder. This is an overview of the potential association between genetics and PAD.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalPostgraduate Medicine
Issue number4
StatePublished - Jul 2010
Externally publishedYes


  • Ankle-brachial index
  • Genetic associations
  • Peripheral artery disease

ASJC Scopus subject areas

  • Medicine(all)


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