Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning

Michelle L. Gabriele, Hiroshi Ishikawa, Gadi Wollstein, Richard A. Bilonick, Larry Kagemann, Maciej Wojtkowski, Vivek Srinivasan, James G. Fujimoto, Jay S. Duker, Joel S. Schuman

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

PURPOSE. TO determine the retinal nerve fiber layer (RNFL) thickness profile in the peripapillary region of healthy eyes. METHODS. Three-dimensional, Fourier/spectral domain optical coherence tomography (OCT) data were obtained as raster scan data (512 X 180 axial scans in a 6 X 6-mm region centered on the optic nerve head [ONH]) with high-speed, ultrahigh-resolution OCT (hsUHR-OCT) from 12 healthy subjects. RNFL thickness was measured on this three-dimensional data set with an in-house software program. The disc margin was defined subjectively in each image and RNFL thickness profiles relative to distance from the disc center were computed for quadrants and clock hours. A mixed-effects model was used to characterize the slope of the profiles. RESULTS. Thickness profiles in the superior, inferior, and temporal quadrants showed an initial increase in RNFL thickness, an area of peak thickness, and a linear decrease as radial distance from the disc center increased. The nasal quadrant showed a constant linear decay without the initial RNFL thickening. A mixed-effects model showed that the slopes of the inferior, superior, and nasal quadrants differed significantly from the temporal slope (P = 0.0012, P = 0.0003, and P = 0.0004, respectively). CONCLUSIONS. RNFL thickness is generally inversely related to the distance from the ONH center in the peripapillary region of healthy subjects, as determined by hsUHR-OCT. However, several areas showed an initial increase in RNFL, followed by a peak and a gradual decrease.

Original languageEnglish (US)
Pages (from-to)3154-3160
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume48
Issue number7
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

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Optical Coherence Tomography
Nerve Fibers
Optic Disk
Nose
Healthy Volunteers
Software

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning. / Gabriele, Michelle L.; Ishikawa, Hiroshi; Wollstein, Gadi; Bilonick, Richard A.; Kagemann, Larry; Wojtkowski, Maciej; Srinivasan, Vivek; Fujimoto, James G.; Duker, Jay S.; Schuman, Joel S.

In: Investigative Ophthalmology and Visual Science, Vol. 48, No. 7, 01.07.2007, p. 3154-3160.

Research output: Contribution to journalArticle

Gabriele, ML, Ishikawa, H, Wollstein, G, Bilonick, RA, Kagemann, L, Wojtkowski, M, Srinivasan, V, Fujimoto, JG, Duker, JS & Schuman, JS 2007, 'Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning', Investigative Ophthalmology and Visual Science, vol. 48, no. 7, pp. 3154-3160. https://doi.org/10.1167/iovs.06-1416
Gabriele, Michelle L. ; Ishikawa, Hiroshi ; Wollstein, Gadi ; Bilonick, Richard A. ; Kagemann, Larry ; Wojtkowski, Maciej ; Srinivasan, Vivek ; Fujimoto, James G. ; Duker, Jay S. ; Schuman, Joel S. / Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning. In: Investigative Ophthalmology and Visual Science. 2007 ; Vol. 48, No. 7. pp. 3154-3160.
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AU - Gabriele, Michelle L.

AU - Ishikawa, Hiroshi

AU - Wollstein, Gadi

AU - Bilonick, Richard A.

AU - Kagemann, Larry

AU - Wojtkowski, Maciej

AU - Srinivasan, Vivek

AU - Fujimoto, James G.

AU - Duker, Jay S.

AU - Schuman, Joel S.

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N2 - PURPOSE. TO determine the retinal nerve fiber layer (RNFL) thickness profile in the peripapillary region of healthy eyes. METHODS. Three-dimensional, Fourier/spectral domain optical coherence tomography (OCT) data were obtained as raster scan data (512 X 180 axial scans in a 6 X 6-mm region centered on the optic nerve head [ONH]) with high-speed, ultrahigh-resolution OCT (hsUHR-OCT) from 12 healthy subjects. RNFL thickness was measured on this three-dimensional data set with an in-house software program. The disc margin was defined subjectively in each image and RNFL thickness profiles relative to distance from the disc center were computed for quadrants and clock hours. A mixed-effects model was used to characterize the slope of the profiles. RESULTS. Thickness profiles in the superior, inferior, and temporal quadrants showed an initial increase in RNFL thickness, an area of peak thickness, and a linear decrease as radial distance from the disc center increased. The nasal quadrant showed a constant linear decay without the initial RNFL thickening. A mixed-effects model showed that the slopes of the inferior, superior, and nasal quadrants differed significantly from the temporal slope (P = 0.0012, P = 0.0003, and P = 0.0004, respectively). CONCLUSIONS. RNFL thickness is generally inversely related to the distance from the ONH center in the peripapillary region of healthy subjects, as determined by hsUHR-OCT. However, several areas showed an initial increase in RNFL, followed by a peak and a gradual decrease.

AB - PURPOSE. TO determine the retinal nerve fiber layer (RNFL) thickness profile in the peripapillary region of healthy eyes. METHODS. Three-dimensional, Fourier/spectral domain optical coherence tomography (OCT) data were obtained as raster scan data (512 X 180 axial scans in a 6 X 6-mm region centered on the optic nerve head [ONH]) with high-speed, ultrahigh-resolution OCT (hsUHR-OCT) from 12 healthy subjects. RNFL thickness was measured on this three-dimensional data set with an in-house software program. The disc margin was defined subjectively in each image and RNFL thickness profiles relative to distance from the disc center were computed for quadrants and clock hours. A mixed-effects model was used to characterize the slope of the profiles. RESULTS. Thickness profiles in the superior, inferior, and temporal quadrants showed an initial increase in RNFL thickness, an area of peak thickness, and a linear decrease as radial distance from the disc center increased. The nasal quadrant showed a constant linear decay without the initial RNFL thickening. A mixed-effects model showed that the slopes of the inferior, superior, and nasal quadrants differed significantly from the temporal slope (P = 0.0012, P = 0.0003, and P = 0.0004, respectively). CONCLUSIONS. RNFL thickness is generally inversely related to the distance from the ONH center in the peripapillary region of healthy subjects, as determined by hsUHR-OCT. However, several areas showed an initial increase in RNFL, followed by a peak and a gradual decrease.

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