Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery

Qian Ding, Zugui Zhang, Hong Liu, Huang Nie, Mark Berguson, Jordan E. Goldhammer, J Nilas Young, Walter D Boyd, Rohinton Morris, Jianzhong Sun

Research output: Contribution to journalArticle

Abstract

It remains disputable about perioperative use of renin-angiotensin system inhibitors (RASi) and their outcome effects. This multicenter retrospective cohort study examines association between use of perioperative RASi and outcomes in patients undergoing coronary artery bypass graft and/or valve surgery. After the exclusion, the patients are divided into 2 groups with or without preoperative RASi (PreRASi, n = 8581), or 2 groups with or without postoperative RASi (PostRASi, n = 8130). With using of propensity scores matching to reduce treatment selection bias, the study shows that PreRASi is associated with a significant reduction in postoperative 30-day mortality compared with without one (3.41% vs. 5.02%); PostRASi is associated with reduced long-term mortality rate compared with without one (6.62% vs. 7.70% at 2-year; 17.09% vs. 19.95% at 6-year). The results suggest that perioperative use of RASi has a significant benefit for the postoperative and long-term survival among patients undergoing cardiac surgery.

Original languageEnglish (US)
Number of pages1
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Sep 13 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Ding, Q., Zhang, Z., Liu, H., Nie, H., Berguson, M., Goldhammer, J. E., Young, J. N., Boyd, W. D., Morris, R., & Sun, J. (2019). Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery. Nature communications, 10(1). https://doi.org/10.1038/s41467-019-11678-9