Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery

Qian Ding; Zugui Zhang; Hong Liu; Huang Nie; Mark Berguson; Jordan E. Goldhammer; Nilas Young; Walter D Boyd; Rohinton Morris; Jianzhong Sun

doi:10.1038/s41467-019-11678-9

Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery

Qian Ding, Zugui Zhang, Hong Liu, Huang Nie, Mark Berguson, Jordan E. Goldhammer, Nilas Young, Walter D Boyd, Rohinton Morris, Jianzhong Sun

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

It remains disputable about perioperative use of renin-angiotensin system inhibitors (RASi) and their outcome effects. This multicenter retrospective cohort study examines association between use of perioperative RASi and outcomes in patients undergoing coronary artery bypass graft and/or valve surgery. After the exclusion, the patients are divided into 2 groups with or without preoperative RASi (PreRASi, n = 8581), or 2 groups with or without postoperative RASi (PostRASi, n = 8130). With using of propensity scores matching to reduce treatment selection bias, the study shows that PreRASi is associated with a significant reduction in postoperative 30-day mortality compared with without one (3.41% vs. 5.02%); PostRASi is associated with reduced long-term mortality rate compared with without one (6.62% vs. 7.70% at 2-year; 17.09% vs. 19.95% at 6-year). The results suggest that perioperative use of RASi has a significant benefit for the postoperative and long-term survival among patients undergoing cardiac surgery.

Original language	English (US)
Number of pages	1
Journal	Nature communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-11678-9
State	Published - Sep 13 2019

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery. / Ding, Qian; Zhang, Zugui; Liu, Hong; Nie, Huang; Berguson, Mark; Goldhammer, Jordan E.; Young, Nilas; Boyd, Walter D; Morris, Rohinton; Sun, Jianzhong.

In: Nature communications, Vol. 10, No. 1, 13.09.2019.

Research output: Contribution to journal › Article › peer-review

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abstract = "It remains disputable about perioperative use of renin-angiotensin system inhibitors (RASi) and their outcome effects. This multicenter retrospective cohort study examines association between use of perioperative RASi and outcomes in patients undergoing coronary artery bypass graft and/or valve surgery. After the exclusion, the patients are divided into 2 groups with or without preoperative RASi (PreRASi, n = 8581), or 2 groups with or without postoperative RASi (PostRASi, n = 8130). With using of propensity scores matching to reduce treatment selection bias, the study shows that PreRASi is associated with a significant reduction in postoperative 30-day mortality compared with without one (3.41% vs. 5.02%); PostRASi is associated with reduced long-term mortality rate compared with without one (6.62% vs. 7.70% at 2-year; 17.09% vs. 19.95% at 6-year). The results suggest that perioperative use of RASi has a significant benefit for the postoperative and long-term survival among patients undergoing cardiac surgery.",

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AU - Young, Nilas

AU - Boyd, Walter D

AU - Morris, Rohinton

AU - Sun, Jianzhong

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Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery

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