TY - JOUR
T1 - Perioperative radiotherapy is associated with improved survival among patients with synovial sarcoma
T2 - A SEER analysis
AU - Naing, Khatija W.
AU - Monjazeb, Arta M
AU - Li, Chin-Shang
AU - Lee, L. I Yuan
AU - Yang, Anthony
AU - Borys, Dariusz
AU - Canter, Robert J
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Background and Methods: We examined the outcomes of synovial sarcoma (SS) patients in a national database. We identified 1,189 patients from the Surveillance, Epidemiology, and End Results (SEER) database with data on site and extent of surgery. We excluded patients diagnosed before 1990, <18 years, or lacking pathologic confirmation. Using Kaplan-Meier and Cox proportional hazards analyses, we determined predictors of overall (OS) and disease-specific survival (DSS). Results: The mean age was 41, 49.3% were female, and 82.2% were white. Radiotherapy (RT) was administered to 57.5%. On multivariable analysis, age at diagnosis, sex, race, anatomic site, SEER summary stage, tumor size, surgery type, and RT predicted OS. Similar predictors of DSS were identified. The hazard ratio (HR) for OS was 0.65 (95% CI 0.48-0.88) in favor of RT and 0.62 (95% CI 0.45-0.86) for DSS. Five-year OS improved 8.4 ± 1.0% with RT (P = 0.003), and five-year DSS improved 7.7 ± 1.0% with RT (P = 0.015). Conclusions: In the largest study to date examining the role of RT in synovial sarcoma, we observed that RT was associated with a statistically significant improvement in oncologic outcome among SS patients. These data support the use of RT in the multi-modality treatment of patients with SS.
AB - Background and Methods: We examined the outcomes of synovial sarcoma (SS) patients in a national database. We identified 1,189 patients from the Surveillance, Epidemiology, and End Results (SEER) database with data on site and extent of surgery. We excluded patients diagnosed before 1990, <18 years, or lacking pathologic confirmation. Using Kaplan-Meier and Cox proportional hazards analyses, we determined predictors of overall (OS) and disease-specific survival (DSS). Results: The mean age was 41, 49.3% were female, and 82.2% were white. Radiotherapy (RT) was administered to 57.5%. On multivariable analysis, age at diagnosis, sex, race, anatomic site, SEER summary stage, tumor size, surgery type, and RT predicted OS. Similar predictors of DSS were identified. The hazard ratio (HR) for OS was 0.65 (95% CI 0.48-0.88) in favor of RT and 0.62 (95% CI 0.45-0.86) for DSS. Five-year OS improved 8.4 ± 1.0% with RT (P = 0.003), and five-year DSS improved 7.7 ± 1.0% with RT (P = 0.015). Conclusions: In the largest study to date examining the role of RT in synovial sarcoma, we observed that RT was associated with a statistically significant improvement in oncologic outcome among SS patients. These data support the use of RT in the multi-modality treatment of patients with SS.
KW - Disease specific survival
KW - Overall survival
KW - Radiation therapy
KW - Radical surgery
KW - Synovial sarcoma
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U2 - 10.1002/jso.23780
DO - 10.1002/jso.23780
M3 - Article
C2 - 25176165
AN - SCOPUS:84921568187
VL - 111
SP - 158
EP - 164
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 2
ER -