Abstract
In humans, perinatal exposure to environmental tobacco smoke (ETS) is associated with neurobehavioral deficits. In the current study, we exposed Rhesus monkeys to ETS in late gestation and in the early neonatal period, and examined changes in neurotransmitter receptors in the brainstem and caudal portion of the cerebral cortex. Nicotinic acetylcholine receptors were markedly upregulated and the effect was selective in that there were no changes in m2-muscarinic acetylcholine receptors or in β-adrenergic receptors. Nicotinic receptor upregulation is indicative of chronic cell stimulation by nicotine, and is a hallmark of nicotine-induced neuroteratogenesis. These results indicate that perinatal ETS exposes the fetus and neonate to quantities of nicotine that are sufficient to alter brain development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-179 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 133 |
| Issue number | 2 |
| State | Published - Feb 28 2002 |
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Keywords
- β-Adrenergic receptor
- Environmental tobacco smoke
- Muscarinic acetylcholine receptor
- Nicotine
- Nicotinic acetylcholine receptor
- Sudden Infant Death Syndrome
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. / Slotkin, T. A.; Pinkerton, Kent E; Auman, J. T.; Qiao, D.; Seidler, F. J.
In: Developmental Brain Research, Vol. 133, No. 2, 28.02.2002, p. 175-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain
AU - Slotkin, T. A.
AU - Pinkerton, Kent E
AU - Auman, J. T.
AU - Qiao, D.
AU - Seidler, F. J.
PY - 2002/2/28
Y1 - 2002/2/28
N2 - In humans, perinatal exposure to environmental tobacco smoke (ETS) is associated with neurobehavioral deficits. In the current study, we exposed Rhesus monkeys to ETS in late gestation and in the early neonatal period, and examined changes in neurotransmitter receptors in the brainstem and caudal portion of the cerebral cortex. Nicotinic acetylcholine receptors were markedly upregulated and the effect was selective in that there were no changes in m2-muscarinic acetylcholine receptors or in β-adrenergic receptors. Nicotinic receptor upregulation is indicative of chronic cell stimulation by nicotine, and is a hallmark of nicotine-induced neuroteratogenesis. These results indicate that perinatal ETS exposes the fetus and neonate to quantities of nicotine that are sufficient to alter brain development.
AB - In humans, perinatal exposure to environmental tobacco smoke (ETS) is associated with neurobehavioral deficits. In the current study, we exposed Rhesus monkeys to ETS in late gestation and in the early neonatal period, and examined changes in neurotransmitter receptors in the brainstem and caudal portion of the cerebral cortex. Nicotinic acetylcholine receptors were markedly upregulated and the effect was selective in that there were no changes in m2-muscarinic acetylcholine receptors or in β-adrenergic receptors. Nicotinic receptor upregulation is indicative of chronic cell stimulation by nicotine, and is a hallmark of nicotine-induced neuroteratogenesis. These results indicate that perinatal ETS exposes the fetus and neonate to quantities of nicotine that are sufficient to alter brain development.
KW - β-Adrenergic receptor
KW - Environmental tobacco smoke
KW - Muscarinic acetylcholine receptor
KW - Nicotine
KW - Nicotinic acetylcholine receptor
KW - Sudden Infant Death Syndrome
UR - http://www.scopus.com/inward/record.url?scp=0037186703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037186703&partnerID=8YFLogxK
M3 - Article
C2 - 11882347
AN - SCOPUS:0037186703
VL - 133
SP - 175
EP - 179
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 2
ER -