Perinatal exposure to environmental tobacco smoke is associated with changes in DNA methylation that precede the adult onset of lung disease in a mouse model

Elizabeth Cole, Traci A. Brown, Kent E Pinkerton, Britten Postma, Keegan Malany, Mihi Yang, Yang Jee Kim, Raymond F. Hamilton, Andrij Holian, Yoon Hee Cho

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Prenatal and early-life environmental tobacco smoke (ETS) exposure can induce epigenetic alterations associated with inflammation and respiratory disease. The objective of this study was to address the long-term epigenetic consequences of perinatal ETS exposure on latent respiratory disease risk, which are still largely unknown. C57BL/6 mice were exposed to prenatal and early-life ETS; offspring lung pathology, global DNA, and gene-specific methylation were measured at two adult ages. Significant alterations in global DNA methylation and promoter methylation of IFN-γ and Thy-1 were found in ETS-exposed offspring at 10–12 and 20 weeks of age. These sustained epigenetic alterations preceded the onset of significant pulmonary pathologies observed at 20 weeks of age. This study suggests that perinatal ETS exposure induces persistent epigenetic alterations in global DNA, as well as IFN-γ and Thy-1 promoter methylation that precede the adult onset of fibrotic lung pathology. These epigenetic findings could represent potential biomarkers of latent respiratory disease risk.

Original languageEnglish (US)
Pages (from-to)435-442
Number of pages8
JournalInhalation Toxicology
Volume29
Issue number10
DOIs
StatePublished - Aug 24 2017

Fingerprint

Pulmonary diseases
Tobacco
Environmental Exposure
DNA Methylation
Epigenomics
Smoke
Lung Diseases
Methylation
Pathology
Lung
DNA
Biomarkers
Inbred C57BL Mouse
Genes
Inflammation

Keywords

  • early life
  • environmental tobacco smoke
  • Inflammation
  • methylation
  • prenatal
  • respiratory disease

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Perinatal exposure to environmental tobacco smoke is associated with changes in DNA methylation that precede the adult onset of lung disease in a mouse model. / Cole, Elizabeth; Brown, Traci A.; Pinkerton, Kent E; Postma, Britten; Malany, Keegan; Yang, Mihi; Kim, Yang Jee; Hamilton, Raymond F.; Holian, Andrij; Cho, Yoon Hee.

In: Inhalation Toxicology, Vol. 29, No. 10, 24.08.2017, p. 435-442.

Research output: Contribution to journalArticle

Cole, Elizabeth ; Brown, Traci A. ; Pinkerton, Kent E ; Postma, Britten ; Malany, Keegan ; Yang, Mihi ; Kim, Yang Jee ; Hamilton, Raymond F. ; Holian, Andrij ; Cho, Yoon Hee. / Perinatal exposure to environmental tobacco smoke is associated with changes in DNA methylation that precede the adult onset of lung disease in a mouse model. In: Inhalation Toxicology. 2017 ; Vol. 29, No. 10. pp. 435-442.
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