Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: Autonomic receptors and the control of adenylyl cyclase activity in heart and lung

T. A. Slotkin, Kent E Pinkerton, F. J. Seidler

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Perinatal exposure to environmental tobacco smoke (ETS) is known to have adverse effects on respiratory function in conjunction with changes in autonomic responses. In the current study, Rhesus monkeys were exposed to ETS during late gestation and in the early neonatal period. Hearts and lungs were examined for changes in β-adrenergic and m2-muscarinic cholinergic receptors, and for alterations in adenylyl cyclase activity. Whereas there were no changes in the heart, there was robust induction of adenylyl cyclase in the lung; previous work with prenatal nicotine exposure in rodent models has shown that adenylyl cyclase induction is associated with a shift towards predominance of cholinergic over adrenergic responses. These data indicate that perinatal ETS exposure evokes changes in cells signaling that they are selective for the lung and that may ultimately reflect adverse effects at the level of physiological function. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalDevelopmental Brain Research
Volume124
Issue number1-2
DOIs
StatePublished - Nov 30 2000

Fingerprint

Environmental Exposure
Adenylyl Cyclases
Smoke
Primates
Tobacco
Adrenergic Agents
Lung
Cholinergic Receptors
Muscarinic Receptors
Macaca mulatta
Nicotine
Cholinergic Agents
Rodentia
Pregnancy

Keywords

  • β-Adrenergic receptor
  • Adenylyl cyclase
  • Cholinergic receptor
  • Environmental tobacco smoke
  • Heart
  • Lung
  • Nicotine
  • Tobacco

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

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abstract = "Perinatal exposure to environmental tobacco smoke (ETS) is known to have adverse effects on respiratory function in conjunction with changes in autonomic responses. In the current study, Rhesus monkeys were exposed to ETS during late gestation and in the early neonatal period. Hearts and lungs were examined for changes in β-adrenergic and m2-muscarinic cholinergic receptors, and for alterations in adenylyl cyclase activity. Whereas there were no changes in the heart, there was robust induction of adenylyl cyclase in the lung; previous work with prenatal nicotine exposure in rodent models has shown that adenylyl cyclase induction is associated with a shift towards predominance of cholinergic over adrenergic responses. These data indicate that perinatal ETS exposure evokes changes in cells signaling that they are selective for the lung and that may ultimately reflect adverse effects at the level of physiological function. (C) 2000 Elsevier Science B.V.",
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AU - Slotkin, T. A.

AU - Pinkerton, Kent E

AU - Seidler, F. J.

PY - 2000/11/30

Y1 - 2000/11/30

N2 - Perinatal exposure to environmental tobacco smoke (ETS) is known to have adverse effects on respiratory function in conjunction with changes in autonomic responses. In the current study, Rhesus monkeys were exposed to ETS during late gestation and in the early neonatal period. Hearts and lungs were examined for changes in β-adrenergic and m2-muscarinic cholinergic receptors, and for alterations in adenylyl cyclase activity. Whereas there were no changes in the heart, there was robust induction of adenylyl cyclase in the lung; previous work with prenatal nicotine exposure in rodent models has shown that adenylyl cyclase induction is associated with a shift towards predominance of cholinergic over adrenergic responses. These data indicate that perinatal ETS exposure evokes changes in cells signaling that they are selective for the lung and that may ultimately reflect adverse effects at the level of physiological function. (C) 2000 Elsevier Science B.V.

AB - Perinatal exposure to environmental tobacco smoke (ETS) is known to have adverse effects on respiratory function in conjunction with changes in autonomic responses. In the current study, Rhesus monkeys were exposed to ETS during late gestation and in the early neonatal period. Hearts and lungs were examined for changes in β-adrenergic and m2-muscarinic cholinergic receptors, and for alterations in adenylyl cyclase activity. Whereas there were no changes in the heart, there was robust induction of adenylyl cyclase in the lung; previous work with prenatal nicotine exposure in rodent models has shown that adenylyl cyclase induction is associated with a shift towards predominance of cholinergic over adrenergic responses. These data indicate that perinatal ETS exposure evokes changes in cells signaling that they are selective for the lung and that may ultimately reflect adverse effects at the level of physiological function. (C) 2000 Elsevier Science B.V.

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KW - Lung

KW - Nicotine

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