Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice

Michele La Merrill, Sunjay Sethi, Ludovic Benard, Erin Moshier, Borje Haraldsson, Christoph Buettner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its use in the 1970s. However, the use of DDT to control vector-borne diseases continues in developing countries. Prenatal DDT exposure is associated with elevated blood pressure in humans. Objective: We hypothesized that perinatal DDT exposure causes hypertension in adult mice. Methods: DDT was administered to C57BL/6J dams from gestational day 11.5 to postnatal day 5. Blood pressure (BP) and myocardial wall thickness were measured in male and female adult offspring. Adult mice were treated with an angiotensin converting enzyme (ACE) inhibitor, captopril, to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhibition. We further assessed the influence of DDT exposure on the expression of mRNAs that regulate BP through renal ion transport. Results: Adult mice perinatally exposed to DDT exhibited chronically increased systolic BP, increased myocardial wall thickness, and elevated expression of mRNAs of several renal ion ŧransporters. Captopril completely reversed hypertension in mice perinatally exposed to DDT. Conclusions: These data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult offspring. A key mechanism underpinning this hypertension is an overactivated renin angiotensin system because ACE inhibition reverses the hypertension induced by perinatal DDT exposure.

Original languageEnglish (US)
Pages (from-to)1722-1727
Number of pages6
JournalEnvironmental Health Perspectives
Volume124
Issue number11
DOIs
StatePublished - Nov 1 2016

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Cardiomegaly
Hypertension
Blood Pressure
Captopril
Peptidyl-Dipeptidase A
Pediculus
Epidemic Louse-Borne Typhus
Kidney
Disease Vectors
Messenger RNA
Plague
Ion Transport
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Developing Countries
Malaria
Ions

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice. / La Merrill, Michele; Sethi, Sunjay; Benard, Ludovic; Moshier, Erin; Haraldsson, Borje; Buettner, Christoph.

In: Environmental Health Perspectives, Vol. 124, No. 11, 01.11.2016, p. 1722-1727.

Research output: Contribution to journalArticle

La Merrill, M, Sethi, S, Benard, L, Moshier, E, Haraldsson, B & Buettner, C 2016, 'Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice', Environmental Health Perspectives, vol. 124, no. 11, pp. 1722-1727. https://doi.org/10.1289/EHP164
La Merrill, Michele ; Sethi, Sunjay ; Benard, Ludovic ; Moshier, Erin ; Haraldsson, Borje ; Buettner, Christoph. / Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice. In: Environmental Health Perspectives. 2016 ; Vol. 124, No. 11. pp. 1722-1727.
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