Periconceptional zinc deficiency affects uterine 3H-estradiol binding in mice

Jeffrey M. Peters, Lynn M. Wiley, Sheri Zidenberg-Cherr, Carl L Keen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To better define the mechanisms by which zinc (Zn) deficiency influences periconceptional development, we examined the effects of this developmental insult on uterine estrogen metabolism. CD-1 mice were assigned to 1 of 3 groups (Low Zn, LZ; Control, C; or Replete, R) and fed either a low Zn (≤0.3 μg Zn/g) or control diet (47 μg Zn/g) 5 days prior to gestation day (GD) 0 and continuing up to GD 4 during early pregnancy. Mice in the R group were fed the low Zn diet until GD 1 after which they were fed the control diet. Uterine 3H-estradiol binding in vivo was measured on GD 2, GD 3, and GD 4. Binding was similar among groups on GD 2 and GD 3, but was lower on GD 4 in LZ mice than in C and R mice (61% of control value). On GD 4, uterine 3H-estradiol binding in vitro was measured and was lower in LZ mice than in C and R mice (63-74% of control values); the reduction in binding was due to lower receptor number. Thus, Zn deficiency can result in a reduction in uterine estradiol receptors and estradiol binding.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalTeratogenesis Carcinogenesis and Mutagenesis
Volume15
Issue number1
StatePublished - 1996

Keywords

  • Development
  • Peri-implantation development
  • Pregnancy
  • Reproduction
  • Uterine estrogen binding
  • Zinc

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis
  • Genetics(clinical)
  • Oncology
  • Toxicology

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    Peters, J. M., Wiley, L. M., Zidenberg-Cherr, S., & Keen, C. L. (1996). Periconceptional zinc deficiency affects uterine 3H-estradiol binding in mice. Teratogenesis Carcinogenesis and Mutagenesis, 15(1), 23-31.