Pericardial reconstruction using an extracellular matrix implant correlates with reduced risk of postoperative atrial fibrillation in coronary artery bypass surgery patients

Walter D Boyd, William E. Johnson, Parvez K. Sultan, Thomas F. Deering, Robert G. Matheny

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32 Citations (Scopus)

Abstract

Background: Postoperative atrial fibrillation (AF) is a significant complication following open heart surgery, with potentially serious clinical and economic implications. To assess the effect of a novel procedure, pericardial reconstruction using a porcine-derived extracellular matrix (ECM) implant, on the risk of postoperative AF after primary isolated coronary artery bypass grafting (CABG), we performed a retrospective comparison of the incidence of postoperative AF in patients who underwent this procedure versus an untreated control group. Methods: We performed a retrospective comparison of the incidence of postoperative AF in 111 patients who underwent a pericardial reconstruction procedure with the CorMatrix ECM for Pericardial Closure (CorMatrix Cardiovascular, Atlanta, GA, USA) following primary isolated CABG, versus a control group of 111 patients who did not undergo pericardial reconstruction. Results: Postoperative AF occurred in 43 of 111 control patients (39%; lower control limit [LCL], 30%; upper control limit [UCL], 49%) but in only 20 of 111 treated patients (18%; LCL, 11%; UCL, 27%). This result represents a 54% reduction in relative risk in the treatment group (P < .001). There was a small but statistically insignificant decrease in the hospital length of stay for the treated patients. The 2 treatment groups exhibited similar postoperative complication profiles. Conclusions: In this retrospective study, pericardial reconstruction with the ECM implant contributed directly to a statistically significant and clinically meaningful reduction in the rate of postoperative AF in patients undergoing primary isolated CABG. A prospective multicenter randomized trial has been planned to further test this approach.

Original languageEnglish (US)
JournalHeart Surgery Forum
Volume13
Issue number5
DOIs
StatePublished - Oct 2010

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Coronary Artery Bypass
Atrial Fibrillation
Extracellular Matrix
Length of Stay
Control Groups
Incidence
Thoracic Surgery
Multicenter Studies
Swine
Retrospective Studies
Economics
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Pericardial reconstruction using an extracellular matrix implant correlates with reduced risk of postoperative atrial fibrillation in coronary artery bypass surgery patients. / Boyd, Walter D; Johnson, William E.; Sultan, Parvez K.; Deering, Thomas F.; Matheny, Robert G.

In: Heart Surgery Forum, Vol. 13, No. 5, 10.2010.

Research output: Contribution to journalArticle

Boyd, Walter D ; Johnson, William E. ; Sultan, Parvez K. ; Deering, Thomas F. ; Matheny, Robert G. / Pericardial reconstruction using an extracellular matrix implant correlates with reduced risk of postoperative atrial fibrillation in coronary artery bypass surgery patients. In: Heart Surgery Forum. 2010 ; Vol. 13, No. 5.
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