Peri-operative blood-loss after total hip arthroplasty can be significantly reduced with topical application of epsilon-aminocaproic acid

Mark G. Sucher, Mauro Giordani, Andrew Figoni, Alexander J. Nedopil

Research output: Contribution to journalArticle

9 Scopus citations


Purpose: To evaluate the peri-operative blood loss with the use of epsilon-aminocaproic acid (ε-ACA) in total hip arthroplasty (THA). Methods: One hundred sixty patients treated with THA were followed; 5 g ε-ACA diluted in 100 ml normal saline was applied intra-operatively. Eighty patients not receiving ε-ACA (non ε-ACA group) and eighty patients receiving ε-ACA (ε-ACA group) were compared regarding blood loss, need of transfusion, and thrombo-embolic complications. Results: Blood loss (mean ± SD) for the non ε-ACA group was 1678 ± 515 ml and for the ε-ACA group 1403 ± 417 ml (p <0.05). In the non ε-ACA group 23 patients needed blood transfusions compared to ten patients in the ε-ACA group (p <0.05). Cost savings were $284.39 per patient. No patient in either group developed a thrombo-embolic complication. Conclusions: This study demonstrates a significant reduction in peri-operative blood loss after THA with topically applied ε-ACA. The application of ε-ACA reduced costs by lowering transfusion rates and did not increase thrombo-embolic events. ε-ACA is safe and effective in reducing blood loss and cost-efficient in THA.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalInternational Orthopaedics
StateAccepted/In press - Jan 8 2016



  • Blood loss
  • Epsilon-aminocaproic acid
  • Total hip arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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