Abstract
Focal cortical dysplasia is the most common malformation of cortical development, causing intractable epilepsy. This study investigated the relationship between brain perfusion and microvessel density in 7 children with focal cortical dysplasia. The authors analyzed brain perfusion measurements obtained by magnetic resonance imaging of 2 of the children and the microvessel density of brain tissue specimens obtained by epilepsy surgery on all of the children. Brain perfusion was approximately 2 times higher in the area of focal cortical dysplasia compared to the contralateral side. The microvessel density was nearly double in the area of focal cortical dysplasia compared to the surrounding cortex that did not have morphological abnormalities. These findings suggest that hyperperfusion can be related to increased microvessel density in focal cortical dysplasia rather than only to seizures. Further investigations are needed to determine the relationship between brain perfusion, microvessel density, and seizure activity.
Original language | English (US) |
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Pages (from-to) | 1474-1482 |
Number of pages | 9 |
Journal | Journal of Child Neurology |
Volume | 28 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2013 |
Keywords
- arterial spin labeling
- brain perfusion
- cerebral blood flow
- focal cortical dysplasia
- magnetic resonance imaging
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health