Abstract
Focal cortical dysplasia is the most common malformation of cortical development, causing intractable epilepsy. This study investigated the relationship between brain perfusion and microvessel density in 7 children with focal cortical dysplasia. The authors analyzed brain perfusion measurements obtained by magnetic resonance imaging of 2 of the children and the microvessel density of brain tissue specimens obtained by epilepsy surgery on all of the children. Brain perfusion was approximately 2 times higher in the area of focal cortical dysplasia compared to the contralateral side. The microvessel density was nearly double in the area of focal cortical dysplasia compared to the surrounding cortex that did not have morphological abnormalities. These findings suggest that hyperperfusion can be related to increased microvessel density in focal cortical dysplasia rather than only to seizures. Further investigations are needed to determine the relationship between brain perfusion, microvessel density, and seizure activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1474-1482 |
| Number of pages | 9 |
| Journal | Journal of Child Neurology |
| Volume | 28 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2013 |
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Keywords
- arterial spin labeling
- brain perfusion
- cerebral blood flow
- focal cortical dysplasia
- magnetic resonance imaging
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
Cite this
Perfusion imaging of focal cortical dysplasia using arterial spin labeling : Correlation with histopathological vascular density. / Wintermark, Pia; Lechpammer, Mirna; Warfield, Simon K.; Kosaras, Bela; Takeoka, Masanori; Poduri, Annapurna; Madsen, Joseph R.; Bergin, Ann M.; Whalen, Stephen; Jensen, Frances E.
In: Journal of Child Neurology, Vol. 28, No. 11, 11.2013, p. 1474-1482.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perfusion imaging of focal cortical dysplasia using arterial spin labeling
T2 - Correlation with histopathological vascular density
AU - Wintermark, Pia
AU - Lechpammer, Mirna
AU - Warfield, Simon K.
AU - Kosaras, Bela
AU - Takeoka, Masanori
AU - Poduri, Annapurna
AU - Madsen, Joseph R.
AU - Bergin, Ann M.
AU - Whalen, Stephen
AU - Jensen, Frances E.
PY - 2013/11
Y1 - 2013/11
N2 - Focal cortical dysplasia is the most common malformation of cortical development, causing intractable epilepsy. This study investigated the relationship between brain perfusion and microvessel density in 7 children with focal cortical dysplasia. The authors analyzed brain perfusion measurements obtained by magnetic resonance imaging of 2 of the children and the microvessel density of brain tissue specimens obtained by epilepsy surgery on all of the children. Brain perfusion was approximately 2 times higher in the area of focal cortical dysplasia compared to the contralateral side. The microvessel density was nearly double in the area of focal cortical dysplasia compared to the surrounding cortex that did not have morphological abnormalities. These findings suggest that hyperperfusion can be related to increased microvessel density in focal cortical dysplasia rather than only to seizures. Further investigations are needed to determine the relationship between brain perfusion, microvessel density, and seizure activity.
AB - Focal cortical dysplasia is the most common malformation of cortical development, causing intractable epilepsy. This study investigated the relationship between brain perfusion and microvessel density in 7 children with focal cortical dysplasia. The authors analyzed brain perfusion measurements obtained by magnetic resonance imaging of 2 of the children and the microvessel density of brain tissue specimens obtained by epilepsy surgery on all of the children. Brain perfusion was approximately 2 times higher in the area of focal cortical dysplasia compared to the contralateral side. The microvessel density was nearly double in the area of focal cortical dysplasia compared to the surrounding cortex that did not have morphological abnormalities. These findings suggest that hyperperfusion can be related to increased microvessel density in focal cortical dysplasia rather than only to seizures. Further investigations are needed to determine the relationship between brain perfusion, microvessel density, and seizure activity.
KW - arterial spin labeling
KW - brain perfusion
KW - cerebral blood flow
KW - focal cortical dysplasia
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84886442328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886442328&partnerID=8YFLogxK
U2 - 10.1177/0883073813488666
DO - 10.1177/0883073813488666
M3 - Article
AN - SCOPUS:84886442328
VL - 28
SP - 1474
EP - 1482
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 11
ER -