Perfusion imaging of focal cortical dysplasia using arterial spin labeling

Correlation with histopathological vascular density

Pia Wintermark, Mirna Lechpammer, Simon K. Warfield, Bela Kosaras, Masanori Takeoka, Annapurna Poduri, Joseph R. Madsen, Ann M. Bergin, Stephen Whalen, Frances E. Jensen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Focal cortical dysplasia is the most common malformation of cortical development, causing intractable epilepsy. This study investigated the relationship between brain perfusion and microvessel density in 7 children with focal cortical dysplasia. The authors analyzed brain perfusion measurements obtained by magnetic resonance imaging of 2 of the children and the microvessel density of brain tissue specimens obtained by epilepsy surgery on all of the children. Brain perfusion was approximately 2 times higher in the area of focal cortical dysplasia compared to the contralateral side. The microvessel density was nearly double in the area of focal cortical dysplasia compared to the surrounding cortex that did not have morphological abnormalities. These findings suggest that hyperperfusion can be related to increased microvessel density in focal cortical dysplasia rather than only to seizures. Further investigations are needed to determine the relationship between brain perfusion, microvessel density, and seizure activity.

Original languageEnglish (US)
Pages (from-to)1474-1482
Number of pages9
JournalJournal of Child Neurology
Volume28
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Malformations of Cortical Development
Perfusion Imaging
Blood Vessels
Microvessels
Perfusion
Brain
Seizures
Epilepsy
Magnetic Resonance Imaging

Keywords

  • arterial spin labeling
  • brain perfusion
  • cerebral blood flow
  • focal cortical dysplasia
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Perfusion imaging of focal cortical dysplasia using arterial spin labeling : Correlation with histopathological vascular density. / Wintermark, Pia; Lechpammer, Mirna; Warfield, Simon K.; Kosaras, Bela; Takeoka, Masanori; Poduri, Annapurna; Madsen, Joseph R.; Bergin, Ann M.; Whalen, Stephen; Jensen, Frances E.

In: Journal of Child Neurology, Vol. 28, No. 11, 11.2013, p. 1474-1482.

Research output: Contribution to journalArticle

Wintermark, P, Lechpammer, M, Warfield, SK, Kosaras, B, Takeoka, M, Poduri, A, Madsen, JR, Bergin, AM, Whalen, S & Jensen, FE 2013, 'Perfusion imaging of focal cortical dysplasia using arterial spin labeling: Correlation with histopathological vascular density', Journal of Child Neurology, vol. 28, no. 11, pp. 1474-1482. https://doi.org/10.1177/0883073813488666
Wintermark, Pia ; Lechpammer, Mirna ; Warfield, Simon K. ; Kosaras, Bela ; Takeoka, Masanori ; Poduri, Annapurna ; Madsen, Joseph R. ; Bergin, Ann M. ; Whalen, Stephen ; Jensen, Frances E. / Perfusion imaging of focal cortical dysplasia using arterial spin labeling : Correlation with histopathological vascular density. In: Journal of Child Neurology. 2013 ; Vol. 28, No. 11. pp. 1474-1482.
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