Abstract
Background: Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) are highly conformal, high-dose radiation treatment techniques used to treat people and dogs with brain tumors. Objectives: To evaluate the response to SRS- and SRT-treated tumors using volume and perfusion variables and to measure the survival times of affected dogs. Animals: Prospective study of 34 dogs with evidence of brain tumors undergoing stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT). Methods: Computed tomography and MRI imaging were used to calculate tumor volume and perfusion at baseline, and at 3 months and 6 months after treatment. Survival analysis was performed to evaluate treatment efficacy. Results: Mean tumor volume significantly declined from baseline to the first recheck by -0.826 cm3 (95% CI: -1.165, -0.487) (P < .001); this reduction was maintained at the second recheck. Blood flow and blood volume declined significantly in the tumor after treatment. Median survival was 324 days (95% CI: 292.8, 419.4), and 4 dogs survived longer than 650 days. Neither actual tumor volume (hazard ratio = 1.21, P = .19) nor the change in tumor volume from the baseline (hazard ratio = 1.38, P = .12) significantly affected the hazard of death because of the tumor. Conclusions and Clinical Importance: Stereotactic radiosurgery and SRT are effective treatments for reducing tumor volume, blood flow, and blood volume. Treated dogs surviving for more than 1 year are more likely to die from other causes than of their primary brain tumor. SRS and SRT should be considered for noninvasive treatment of intracranial brain tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 827-835 |
| Number of pages | 9 |
| Journal | Journal of Veterinary Internal Medicine |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1 2016 |
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Keywords
- Blood flow
- Dog
- Pituitary
- Radiation
ASJC Scopus subject areas
- veterinary(all)
Cite this
Perfusion and Volume Response of Canine Brain Tumors to Stereotactic Radiosurgery and Radiotherapy. / Zwingenberger, Allison; Pollard, Rachel E; Taylor, S. L.; Chen, R. X.; Nunley, J.; Kent, Michael S.
In: Journal of Veterinary Internal Medicine, Vol. 30, No. 3, 01.05.2016, p. 827-835.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perfusion and Volume Response of Canine Brain Tumors to Stereotactic Radiosurgery and Radiotherapy
AU - Zwingenberger, Allison
AU - Pollard, Rachel E
AU - Taylor, S. L.
AU - Chen, R. X.
AU - Nunley, J.
AU - Kent, Michael S
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background: Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) are highly conformal, high-dose radiation treatment techniques used to treat people and dogs with brain tumors. Objectives: To evaluate the response to SRS- and SRT-treated tumors using volume and perfusion variables and to measure the survival times of affected dogs. Animals: Prospective study of 34 dogs with evidence of brain tumors undergoing stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT). Methods: Computed tomography and MRI imaging were used to calculate tumor volume and perfusion at baseline, and at 3 months and 6 months after treatment. Survival analysis was performed to evaluate treatment efficacy. Results: Mean tumor volume significantly declined from baseline to the first recheck by -0.826 cm3 (95% CI: -1.165, -0.487) (P < .001); this reduction was maintained at the second recheck. Blood flow and blood volume declined significantly in the tumor after treatment. Median survival was 324 days (95% CI: 292.8, 419.4), and 4 dogs survived longer than 650 days. Neither actual tumor volume (hazard ratio = 1.21, P = .19) nor the change in tumor volume from the baseline (hazard ratio = 1.38, P = .12) significantly affected the hazard of death because of the tumor. Conclusions and Clinical Importance: Stereotactic radiosurgery and SRT are effective treatments for reducing tumor volume, blood flow, and blood volume. Treated dogs surviving for more than 1 year are more likely to die from other causes than of their primary brain tumor. SRS and SRT should be considered for noninvasive treatment of intracranial brain tumors.
AB - Background: Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) are highly conformal, high-dose radiation treatment techniques used to treat people and dogs with brain tumors. Objectives: To evaluate the response to SRS- and SRT-treated tumors using volume and perfusion variables and to measure the survival times of affected dogs. Animals: Prospective study of 34 dogs with evidence of brain tumors undergoing stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT). Methods: Computed tomography and MRI imaging were used to calculate tumor volume and perfusion at baseline, and at 3 months and 6 months after treatment. Survival analysis was performed to evaluate treatment efficacy. Results: Mean tumor volume significantly declined from baseline to the first recheck by -0.826 cm3 (95% CI: -1.165, -0.487) (P < .001); this reduction was maintained at the second recheck. Blood flow and blood volume declined significantly in the tumor after treatment. Median survival was 324 days (95% CI: 292.8, 419.4), and 4 dogs survived longer than 650 days. Neither actual tumor volume (hazard ratio = 1.21, P = .19) nor the change in tumor volume from the baseline (hazard ratio = 1.38, P = .12) significantly affected the hazard of death because of the tumor. Conclusions and Clinical Importance: Stereotactic radiosurgery and SRT are effective treatments for reducing tumor volume, blood flow, and blood volume. Treated dogs surviving for more than 1 year are more likely to die from other causes than of their primary brain tumor. SRS and SRT should be considered for noninvasive treatment of intracranial brain tumors.
KW - Blood flow
KW - Dog
KW - Pituitary
KW - Radiation
UR - http://www.scopus.com/inward/record.url?scp=84965062807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965062807&partnerID=8YFLogxK
U2 - 10.1111/jvim.13945
DO - 10.1111/jvim.13945
M3 - Article
VL - 30
SP - 827
EP - 835
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 3
ER -