Abstract
PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 x 10 lutetium oxyorthosilicate crystal arrays and 3 x 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 639-647 |
| Number of pages | 9 |
| Journal | Journal of Nuclear Medicine |
| Volume | 47 |
| Issue number | 4 |
| State | Published - Apr 1 2006 |
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Keywords
- Animal imaging
- Instrumentation
- Molecular imaging
- Multimodality imaging
- PET
- PET/MRI development
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. / Pichler, Bernd J.; Judenhofer, Martin S.; Catana, Ciprian; Walton, Jeffrey H.; Kneilling, Manfred; Nutt, Robert E.; Siegel, Stefan B.; Claussen, Claus D.; Cherry, Simon R.
In: Journal of Nuclear Medicine, Vol. 47, No. 4, 01.04.2006, p. 639-647.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI
AU - Pichler, Bernd J.
AU - Judenhofer, Martin S.
AU - Catana, Ciprian
AU - Walton, Jeffrey H.
AU - Kneilling, Manfred
AU - Nutt, Robert E.
AU - Siegel, Stefan B.
AU - Claussen, Claus D.
AU - Cherry, Simon R
PY - 2006/4/1
Y1 - 2006/4/1
N2 - PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 x 10 lutetium oxyorthosilicate crystal arrays and 3 x 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.
AB - PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 x 10 lutetium oxyorthosilicate crystal arrays and 3 x 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.
KW - Animal imaging
KW - Instrumentation
KW - Molecular imaging
KW - Multimodality imaging
KW - PET
KW - PET/MRI development
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UR - http://www.scopus.com/inward/citedby.url?scp=33745111311&partnerID=8YFLogxK
M3 - Article
C2 - 16595498
AN - SCOPUS:33745111311
VL - 47
SP - 639
EP - 647
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 4
ER -