Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI

Bernd J. Pichler, Martin S. Judenhofer, Ciprian Catana, Jeffrey H. Walton, Manfred Kneilling, Robert E. Nutt, Stefan B. Siegel, Claus D. Claussen, Simon R Cherry

Research output: Contribution to journalArticle

336 Scopus citations

Abstract

PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 x 10 lutetium oxyorthosilicate crystal arrays and 3 x 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.

Original languageEnglish (US)
Pages (from-to)639-647
Number of pages9
JournalJournal of Nuclear Medicine
Volume47
Issue number4
StatePublished - Apr 1 2006

Keywords

  • Animal imaging
  • Instrumentation
  • Molecular imaging
  • Multimodality imaging
  • PET
  • PET/MRI development

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI'. Together they form a unique fingerprint.

  • Cite this

    Pichler, B. J., Judenhofer, M. S., Catana, C., Walton, J. H., Kneilling, M., Nutt, R. E., Siegel, S. B., Claussen, C. D., & Cherry, S. R. (2006). Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. Journal of Nuclear Medicine, 47(4), 639-647.