Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI

Bernd J. Pichler, Martin S. Judenhofer, Ciprian Catana, Jeffrey H. Walton, Manfred Kneilling, Robert E. Nutt, Stefan B. Siegel, Claus D. Claussen, Simon R Cherry

Research output: Contribution to journalArticle

333 Citations (Scopus)

Abstract

PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 x 10 lutetium oxyorthosilicate crystal arrays and 3 x 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.

Original languageEnglish (US)
Pages (from-to)639-647
Number of pages9
JournalJournal of Nuclear Medicine
Volume47
Issue number4
StatePublished - Apr 1 2006

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Magnetic Fields
Ionizing Radiation
Contrast Media
Radiation
Technology
Equipment and Supplies

Keywords

  • Animal imaging
  • Instrumentation
  • Molecular imaging
  • Multimodality imaging
  • PET
  • PET/MRI development

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Pichler, B. J., Judenhofer, M. S., Catana, C., Walton, J. H., Kneilling, M., Nutt, R. E., ... Cherry, S. R. (2006). Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. Journal of Nuclear Medicine, 47(4), 639-647.

Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. / Pichler, Bernd J.; Judenhofer, Martin S.; Catana, Ciprian; Walton, Jeffrey H.; Kneilling, Manfred; Nutt, Robert E.; Siegel, Stefan B.; Claussen, Claus D.; Cherry, Simon R.

In: Journal of Nuclear Medicine, Vol. 47, No. 4, 01.04.2006, p. 639-647.

Research output: Contribution to journalArticle

Pichler, BJ, Judenhofer, MS, Catana, C, Walton, JH, Kneilling, M, Nutt, RE, Siegel, SB, Claussen, CD & Cherry, SR 2006, 'Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI', Journal of Nuclear Medicine, vol. 47, no. 4, pp. 639-647.
Pichler BJ, Judenhofer MS, Catana C, Walton JH, Kneilling M, Nutt RE et al. Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. Journal of Nuclear Medicine. 2006 Apr 1;47(4):639-647.
Pichler, Bernd J. ; Judenhofer, Martin S. ; Catana, Ciprian ; Walton, Jeffrey H. ; Kneilling, Manfred ; Nutt, Robert E. ; Siegel, Stefan B. ; Claussen, Claus D. ; Cherry, Simon R. / Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. In: Journal of Nuclear Medicine. 2006 ; Vol. 47, No. 4. pp. 639-647.
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