Abstract
Trauma of the nervous system often results in permanent functional loss because the spontaneous regeneration of nerves is very difficult. Thus, various methods have been developed to facilitate the restoration of damaged nerve. The biodegradable nerve conduit is one of the most promising methods for nerve regeneration. Chitosan, a natural polysaccharide that has excellent biocompatibility and biodegradability, can be used as conduit material. But, nerves regenerated by nerve conduits made from chitosan have some problems, for example, with their mechanical properties. This article shows that the mechanical properties of chitosan film were markedly improved by selected doses of gamma radiation and cell culturing experiments on the surface of the irradiated chitosan film indicated that the film still has excellent biocompatibility.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-226 |
| Number of pages | 12 |
| Journal | Journal of Biomaterials Applications |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2002 |
| Externally published | Yes |
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Keywords
- Biocompatibility
- Chitosan
- Gamma ray
- Mechanical property
- Nerve cell affinity
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
Cite this
Performance modification of chitosan membranes induced by gamma irradiation. / Yang, Fei; Li, Xunhu; Cheng, Mingyu; Gong, Yandao; Zhao, Nanming; Zhang, Xiufang; Yang, Yinye.
In: Journal of Biomaterials Applications, Vol. 16, No. 3, 01.01.2002, p. 215-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Performance modification of chitosan membranes induced by gamma irradiation
AU - Yang, Fei
AU - Li, Xunhu
AU - Cheng, Mingyu
AU - Gong, Yandao
AU - Zhao, Nanming
AU - Zhang, Xiufang
AU - Yang, Yinye
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Trauma of the nervous system often results in permanent functional loss because the spontaneous regeneration of nerves is very difficult. Thus, various methods have been developed to facilitate the restoration of damaged nerve. The biodegradable nerve conduit is one of the most promising methods for nerve regeneration. Chitosan, a natural polysaccharide that has excellent biocompatibility and biodegradability, can be used as conduit material. But, nerves regenerated by nerve conduits made from chitosan have some problems, for example, with their mechanical properties. This article shows that the mechanical properties of chitosan film were markedly improved by selected doses of gamma radiation and cell culturing experiments on the surface of the irradiated chitosan film indicated that the film still has excellent biocompatibility.
AB - Trauma of the nervous system often results in permanent functional loss because the spontaneous regeneration of nerves is very difficult. Thus, various methods have been developed to facilitate the restoration of damaged nerve. The biodegradable nerve conduit is one of the most promising methods for nerve regeneration. Chitosan, a natural polysaccharide that has excellent biocompatibility and biodegradability, can be used as conduit material. But, nerves regenerated by nerve conduits made from chitosan have some problems, for example, with their mechanical properties. This article shows that the mechanical properties of chitosan film were markedly improved by selected doses of gamma radiation and cell culturing experiments on the surface of the irradiated chitosan film indicated that the film still has excellent biocompatibility.
KW - Biocompatibility
KW - Chitosan
KW - Gamma ray
KW - Mechanical property
KW - Nerve cell affinity
UR - http://www.scopus.com/inward/record.url?scp=0036009173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036009173&partnerID=8YFLogxK
U2 - 10.1177/0885328202016003176
DO - 10.1177/0885328202016003176
M3 - Article
C2 - 11939456
AN - SCOPUS:0036009173
VL - 16
SP - 215
EP - 226
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
SN - 0885-3282
IS - 3
ER -