Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection

Máire F. Quigley, Kristina Abel, Bartek Zuber, Chris J Miller, Johan K. Sandberg, Barbara Shacklett

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Perforin-mediated cytotoxicity is a major effector function of virus-specific CD8 T cells. We have investigated the expression of perform in the gut, an important site of simian immunodeficiency virus (SIV) pathogenesis, during experimental SIV infection of rhesus macaques. We observed significant increases in perforin protein and mRNA expression levels in the colons of SIV-infected macaques as early as 21 days after infection. However, during chronic infection, despite ongoing viral replication, perforin expression returned to levels similar to those detected in SIV-naïve animals. These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection.

Original languageEnglish (US)
Pages (from-to)3083-3087
Number of pages5
JournalJournal of Virology
Volume80
Issue number6
DOIs
StatePublished - Mar 2006

Fingerprint

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Perforin
Virus Diseases
mucosa
Mucous Membrane
infection
T-lymphocytes
T-Lymphocytes
Macaca
virus replication
Macaca mulatta
Infection
colon
cytotoxicity
Colon
pathogenesis
digestive system
Viruses
viruses

ASJC Scopus subject areas

  • Immunology

Cite this

Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection. / Quigley, Máire F.; Abel, Kristina; Zuber, Bartek; Miller, Chris J; Sandberg, Johan K.; Shacklett, Barbara.

In: Journal of Virology, Vol. 80, No. 6, 03.2006, p. 3083-3087.

Research output: Contribution to journalArticle

Quigley, Máire F. ; Abel, Kristina ; Zuber, Bartek ; Miller, Chris J ; Sandberg, Johan K. ; Shacklett, Barbara. / Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection. In: Journal of Virology. 2006 ; Vol. 80, No. 6. pp. 3083-3087.
@article{5f316fa8c172461cb0b171261b0a0387,
title = "Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection",
abstract = "Perforin-mediated cytotoxicity is a major effector function of virus-specific CD8 T cells. We have investigated the expression of perform in the gut, an important site of simian immunodeficiency virus (SIV) pathogenesis, during experimental SIV infection of rhesus macaques. We observed significant increases in perforin protein and mRNA expression levels in the colons of SIV-infected macaques as early as 21 days after infection. However, during chronic infection, despite ongoing viral replication, perforin expression returned to levels similar to those detected in SIV-na{\"i}ve animals. These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection.",
author = "Quigley, {M{\'a}ire F.} and Kristina Abel and Bartek Zuber and Miller, {Chris J} and Sandberg, {Johan K.} and Barbara Shacklett",
year = "2006",
month = "3",
doi = "10.1128/JVI.80.6.3083-3087.2006",
language = "English (US)",
volume = "80",
pages = "3083--3087",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection

AU - Quigley, Máire F.

AU - Abel, Kristina

AU - Zuber, Bartek

AU - Miller, Chris J

AU - Sandberg, Johan K.

AU - Shacklett, Barbara

PY - 2006/3

Y1 - 2006/3

N2 - Perforin-mediated cytotoxicity is a major effector function of virus-specific CD8 T cells. We have investigated the expression of perform in the gut, an important site of simian immunodeficiency virus (SIV) pathogenesis, during experimental SIV infection of rhesus macaques. We observed significant increases in perforin protein and mRNA expression levels in the colons of SIV-infected macaques as early as 21 days after infection. However, during chronic infection, despite ongoing viral replication, perforin expression returned to levels similar to those detected in SIV-naïve animals. These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection.

AB - Perforin-mediated cytotoxicity is a major effector function of virus-specific CD8 T cells. We have investigated the expression of perform in the gut, an important site of simian immunodeficiency virus (SIV) pathogenesis, during experimental SIV infection of rhesus macaques. We observed significant increases in perforin protein and mRNA expression levels in the colons of SIV-infected macaques as early as 21 days after infection. However, during chronic infection, despite ongoing viral replication, perforin expression returned to levels similar to those detected in SIV-naïve animals. These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection.

UR - http://www.scopus.com/inward/record.url?scp=33644772169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644772169&partnerID=8YFLogxK

U2 - 10.1128/JVI.80.6.3083-3087.2006

DO - 10.1128/JVI.80.6.3083-3087.2006

M3 - Article

VL - 80

SP - 3083

EP - 3087

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 6

ER -