Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis

Christian M. Lo Cascio, Mirja Quante, Eric A. Hoffman, Alain G. Bertoni, Carrie P. Aaron, Joseph E. Schwartz, Mark V Avdalovic, Vincent S. Fan, Gina S. Lovasi, Steven M. Kawut, John H.M. Austin, Susan Redline, R. Graham Barr

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like lung on CT scan is associated with reduced physical activity assessed by actigraphy and self-report. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants free of clinical cardiovascular disease from the general population. Percent emphysema was defined as percentage of voxels < −950 Hounsfield units on full-lung CT scans. Physical activity was measured by wrist actigraphy over 7 days and a questionnaire. Multivariable linear regression was used to adjust for age, sex, race/ethnicity, height, weight, education, smoking, pack-years, and lung function. Results Among 1,435 participants with actigraphy and lung measures, 47% had never smoked, and 8% had COPD. Percent emphysema was associated with lower activity levels on actigraphy (P =.001), corresponding to 1.5 hour less per week of moderately paced walking for the average participant in quintile 2 vs 4 of percent emphysema. This association was significant among participants without COPD (P =.004) and among ever (P =.01) and never smokers (P =.03). It was also independent of coronary artery calcium and left ventricular ejection fraction. There was no evidence that percent emphysema was associated with self-reported activity levels. Conclusions Percent emphysema was associated with decreased physical activity in daily life objectively assessed by actigraphy in the general population, among participants without COPD, and nonsmokers.

Original languageEnglish (US)
Pages (from-to)1039-1050
Number of pages12
JournalChest
Volume151
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Actigraphy
Emphysema
Chronic Obstructive Pulmonary Disease
Atherosclerosis
Motor Activity
Exercise
Population
Lung
Pulmonary Emphysema
Wrist
Stroke Volume
Self Report
Walking
Linear Models
Coronary Vessels
Cardiovascular Diseases
Smoking
Calcium
Education
Weights and Measures

Keywords

  • actigraphy
  • computed tomography
  • emphysema
  • multicenter prospective cohort study
  • physical activity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lo Cascio, C. M., Quante, M., Hoffman, E. A., Bertoni, A. G., Aaron, C. P., Schwartz, J. E., ... Barr, R. G. (2017). Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis. Chest, 151(5), 1039-1050. https://doi.org/10.1016/j.chest.2016.11.033

Percent Emphysema and Daily Motor Activity Levels in the General Population : Multi-Ethnic Study of Atherosclerosis. / Lo Cascio, Christian M.; Quante, Mirja; Hoffman, Eric A.; Bertoni, Alain G.; Aaron, Carrie P.; Schwartz, Joseph E.; Avdalovic, Mark V; Fan, Vincent S.; Lovasi, Gina S.; Kawut, Steven M.; Austin, John H.M.; Redline, Susan; Barr, R. Graham.

In: Chest, Vol. 151, No. 5, 01.05.2017, p. 1039-1050.

Research output: Contribution to journalArticle

Lo Cascio, CM, Quante, M, Hoffman, EA, Bertoni, AG, Aaron, CP, Schwartz, JE, Avdalovic, MV, Fan, VS, Lovasi, GS, Kawut, SM, Austin, JHM, Redline, S & Barr, RG 2017, 'Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis', Chest, vol. 151, no. 5, pp. 1039-1050. https://doi.org/10.1016/j.chest.2016.11.033
Lo Cascio CM, Quante M, Hoffman EA, Bertoni AG, Aaron CP, Schwartz JE et al. Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis. Chest. 2017 May 1;151(5):1039-1050. https://doi.org/10.1016/j.chest.2016.11.033
Lo Cascio, Christian M. ; Quante, Mirja ; Hoffman, Eric A. ; Bertoni, Alain G. ; Aaron, Carrie P. ; Schwartz, Joseph E. ; Avdalovic, Mark V ; Fan, Vincent S. ; Lovasi, Gina S. ; Kawut, Steven M. ; Austin, John H.M. ; Redline, Susan ; Barr, R. Graham. / Percent Emphysema and Daily Motor Activity Levels in the General Population : Multi-Ethnic Study of Atherosclerosis. In: Chest. 2017 ; Vol. 151, No. 5. pp. 1039-1050.
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abstract = "Background COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like lung on CT scan is associated with reduced physical activity assessed by actigraphy and self-report. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants free of clinical cardiovascular disease from the general population. Percent emphysema was defined as percentage of voxels < −950 Hounsfield units on full-lung CT scans. Physical activity was measured by wrist actigraphy over 7 days and a questionnaire. Multivariable linear regression was used to adjust for age, sex, race/ethnicity, height, weight, education, smoking, pack-years, and lung function. Results Among 1,435 participants with actigraphy and lung measures, 47{\%} had never smoked, and 8{\%} had COPD. Percent emphysema was associated with lower activity levels on actigraphy (P =.001), corresponding to 1.5 hour less per week of moderately paced walking for the average participant in quintile 2 vs 4 of percent emphysema. This association was significant among participants without COPD (P =.004) and among ever (P =.01) and never smokers (P =.03). It was also independent of coronary artery calcium and left ventricular ejection fraction. There was no evidence that percent emphysema was associated with self-reported activity levels. Conclusions Percent emphysema was associated with decreased physical activity in daily life objectively assessed by actigraphy in the general population, among participants without COPD, and nonsmokers.",
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AU - Lo Cascio, Christian M.

AU - Quante, Mirja

AU - Hoffman, Eric A.

AU - Bertoni, Alain G.

AU - Aaron, Carrie P.

AU - Schwartz, Joseph E.

AU - Avdalovic, Mark V

AU - Fan, Vincent S.

AU - Lovasi, Gina S.

AU - Kawut, Steven M.

AU - Austin, John H.M.

AU - Redline, Susan

AU - Barr, R. Graham

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N2 - Background COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like lung on CT scan is associated with reduced physical activity assessed by actigraphy and self-report. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants free of clinical cardiovascular disease from the general population. Percent emphysema was defined as percentage of voxels < −950 Hounsfield units on full-lung CT scans. Physical activity was measured by wrist actigraphy over 7 days and a questionnaire. Multivariable linear regression was used to adjust for age, sex, race/ethnicity, height, weight, education, smoking, pack-years, and lung function. Results Among 1,435 participants with actigraphy and lung measures, 47% had never smoked, and 8% had COPD. Percent emphysema was associated with lower activity levels on actigraphy (P =.001), corresponding to 1.5 hour less per week of moderately paced walking for the average participant in quintile 2 vs 4 of percent emphysema. This association was significant among participants without COPD (P =.004) and among ever (P =.01) and never smokers (P =.03). It was also independent of coronary artery calcium and left ventricular ejection fraction. There was no evidence that percent emphysema was associated with self-reported activity levels. Conclusions Percent emphysema was associated with decreased physical activity in daily life objectively assessed by actigraphy in the general population, among participants without COPD, and nonsmokers.

AB - Background COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like lung on CT scan is associated with reduced physical activity assessed by actigraphy and self-report. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants free of clinical cardiovascular disease from the general population. Percent emphysema was defined as percentage of voxels < −950 Hounsfield units on full-lung CT scans. Physical activity was measured by wrist actigraphy over 7 days and a questionnaire. Multivariable linear regression was used to adjust for age, sex, race/ethnicity, height, weight, education, smoking, pack-years, and lung function. Results Among 1,435 participants with actigraphy and lung measures, 47% had never smoked, and 8% had COPD. Percent emphysema was associated with lower activity levels on actigraphy (P =.001), corresponding to 1.5 hour less per week of moderately paced walking for the average participant in quintile 2 vs 4 of percent emphysema. This association was significant among participants without COPD (P =.004) and among ever (P =.01) and never smokers (P =.03). It was also independent of coronary artery calcium and left ventricular ejection fraction. There was no evidence that percent emphysema was associated with self-reported activity levels. Conclusions Percent emphysema was associated with decreased physical activity in daily life objectively assessed by actigraphy in the general population, among participants without COPD, and nonsmokers.

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