Abstract
Adverse effects from antiretroviral therapy (ARV) for HIV are associated with medication nonadherence. The purposes of this study were to explore group differences in the reporting of adverse effects, identify individual adverse effects that are linked to nonadherence, and to explore the role of coping in the relationship between adverse effects and adherence. Cross-sectional interviews of 2,765 HIV-positive adults on ARV therapies in four U.S. cities were performed using a computerized assessment of self-reported adverse effects, coping self-efficacy, and adherence. There were no gender differences in the rate or severity of adverse effects reported. Latino respondents reported more adverse effects than either White or African Americans. Those taking a protease inhibitor (PI) reported a higher rate and greater severity of adverse effects. Older participants reported fewer adverse effects despite being more likely to be on a regimen containing a PI. Respondents with less than 90% adherence reported greater numbers and severity of adverse effects overall. In multivariate analyses, nausea, skin problems, vomiting, and memory adverse effects were independently related to less than 90% adherence over the prior three days. Coping moderated the relationship between nausea and adherence such that individuals who reported lower coping self-efficacy and experienced nausea were at increased risk for nonadherence, regardless of the length of time on the current ARV regimen. Women and men are similar in their overall reports of adverse effects, and Latinos report more adverse effects to ARVs than White or African American patients. Specific adverse effects (skin problems, memory problems, vomiting, and nausea) are more likely than others to be associated with missing ARV medications. Increasing adaptive coping self-efficacy among patients experiencing nausea may be a particularly effective strategy in increasing medication adherence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 193-205 |
| Number of pages | 13 |
| Journal | Journal of Pain and Symptom Management |
| Volume | 29 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2005 |
| Externally published | Yes |
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Keywords
- Adherence
- Adverse effects
- Antiretroviral therapy
- Coping
- HAART
- HIV/AIDS
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Clinical Neurology
- Neurology
- Nursing(all)
Cite this
Perceived adverse effects of antiretroviral therapy. / Johnson, Mallory O.; Charlebois, Edwin; Morin, Stephen F.; Catz, Sheryl L; Goldstein, Rise B.; Remien, Robert H.; Rotheram-Borus, Mary Jane; Mickalian, Joanne D.; Kittel, Lauren; Samimy-Muzaffar, Farishta; Lightfoot, Marguerita A.; Gore-Felton, Cheryl; Chesney, Margaret A.
In: Journal of Pain and Symptom Management, Vol. 29, No. 2, 02.2005, p. 193-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perceived adverse effects of antiretroviral therapy
AU - Johnson, Mallory O.
AU - Charlebois, Edwin
AU - Morin, Stephen F.
AU - Catz, Sheryl L
AU - Goldstein, Rise B.
AU - Remien, Robert H.
AU - Rotheram-Borus, Mary Jane
AU - Mickalian, Joanne D.
AU - Kittel, Lauren
AU - Samimy-Muzaffar, Farishta
AU - Lightfoot, Marguerita A.
AU - Gore-Felton, Cheryl
AU - Chesney, Margaret A.
PY - 2005/2
Y1 - 2005/2
N2 - Adverse effects from antiretroviral therapy (ARV) for HIV are associated with medication nonadherence. The purposes of this study were to explore group differences in the reporting of adverse effects, identify individual adverse effects that are linked to nonadherence, and to explore the role of coping in the relationship between adverse effects and adherence. Cross-sectional interviews of 2,765 HIV-positive adults on ARV therapies in four U.S. cities were performed using a computerized assessment of self-reported adverse effects, coping self-efficacy, and adherence. There were no gender differences in the rate or severity of adverse effects reported. Latino respondents reported more adverse effects than either White or African Americans. Those taking a protease inhibitor (PI) reported a higher rate and greater severity of adverse effects. Older participants reported fewer adverse effects despite being more likely to be on a regimen containing a PI. Respondents with less than 90% adherence reported greater numbers and severity of adverse effects overall. In multivariate analyses, nausea, skin problems, vomiting, and memory adverse effects were independently related to less than 90% adherence over the prior three days. Coping moderated the relationship between nausea and adherence such that individuals who reported lower coping self-efficacy and experienced nausea were at increased risk for nonadherence, regardless of the length of time on the current ARV regimen. Women and men are similar in their overall reports of adverse effects, and Latinos report more adverse effects to ARVs than White or African American patients. Specific adverse effects (skin problems, memory problems, vomiting, and nausea) are more likely than others to be associated with missing ARV medications. Increasing adaptive coping self-efficacy among patients experiencing nausea may be a particularly effective strategy in increasing medication adherence.
AB - Adverse effects from antiretroviral therapy (ARV) for HIV are associated with medication nonadherence. The purposes of this study were to explore group differences in the reporting of adverse effects, identify individual adverse effects that are linked to nonadherence, and to explore the role of coping in the relationship between adverse effects and adherence. Cross-sectional interviews of 2,765 HIV-positive adults on ARV therapies in four U.S. cities were performed using a computerized assessment of self-reported adverse effects, coping self-efficacy, and adherence. There were no gender differences in the rate or severity of adverse effects reported. Latino respondents reported more adverse effects than either White or African Americans. Those taking a protease inhibitor (PI) reported a higher rate and greater severity of adverse effects. Older participants reported fewer adverse effects despite being more likely to be on a regimen containing a PI. Respondents with less than 90% adherence reported greater numbers and severity of adverse effects overall. In multivariate analyses, nausea, skin problems, vomiting, and memory adverse effects were independently related to less than 90% adherence over the prior three days. Coping moderated the relationship between nausea and adherence such that individuals who reported lower coping self-efficacy and experienced nausea were at increased risk for nonadherence, regardless of the length of time on the current ARV regimen. Women and men are similar in their overall reports of adverse effects, and Latinos report more adverse effects to ARVs than White or African American patients. Specific adverse effects (skin problems, memory problems, vomiting, and nausea) are more likely than others to be associated with missing ARV medications. Increasing adaptive coping self-efficacy among patients experiencing nausea may be a particularly effective strategy in increasing medication adherence.
KW - Adherence
KW - Adverse effects
KW - Antiretroviral therapy
KW - Coping
KW - HAART
KW - HIV/AIDS
UR - http://www.scopus.com/inward/record.url?scp=20044385406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20044385406&partnerID=8YFLogxK
U2 - 10.1016/j.jpainsymman.2004.05.005
DO - 10.1016/j.jpainsymman.2004.05.005
M3 - Article
C2 - 15793937
AN - SCOPUS:20044385406
VL - 29
SP - 193
EP - 205
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
SN - 0885-3924
IS - 2
ER -