Peptide Quinoline Conjugates: A New Class of RNA-Binding Molecules

Malathy Krishnamurthy, Barry D. Gooch, Peter A. Beal

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

(Equation presented) A synthesis of 4,8-disubstituted 2-phenylquinoline amino acids is reported with the incorporation of one example into a peptide by solid-phase synthesis. The phenylquinoline-containing peptide binds an RNA target with nanomolar affinity (KD = 208 nM). The strategy can be used to prepare a variety of 2-substituted quinoline amino acids for alteration of affinity in intercalator peptides. Since quinolones represent an important class of antibacterials, these compounds may be useful in the discovery of new antibacterial agents.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalOrganic Letters
Volume6
Issue number1
DOIs
StatePublished - Jan 8 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine

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