Peptide Quinoline Conjugates

A New Class of RNA-Binding Molecules

Malathy Krishnamurthy, Barry D. Gooch, Peter A. Beal

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

(Equation presented) A synthesis of 4,8-disubstituted 2-phenylquinoline amino acids is reported with the incorporation of one example into a peptide by solid-phase synthesis. The phenylquinoline-containing peptide binds an RNA target with nanomolar affinity (KD = 208 nM). The strategy can be used to prepare a variety of 2-substituted quinoline amino acids for alteration of affinity in intercalator peptides. Since quinolones represent an important class of antibacterials, these compounds may be useful in the discovery of new antibacterial agents.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalOrganic Letters
Volume6
Issue number1
DOIs
StatePublished - Jan 8 2004
Externally publishedYes

Fingerprint

quinoline
peptides
RNA
Intercalating Agents
Amino Acids
Peptides
Solid-Phase Synthesis Techniques
Molecules
amino acids
affinity
Quinolones
molecules
synthesis
Anti-Bacterial Agents
solid phases
2-phenylquinoline

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Peptide Quinoline Conjugates : A New Class of RNA-Binding Molecules. / Krishnamurthy, Malathy; Gooch, Barry D.; Beal, Peter A.

In: Organic Letters, Vol. 6, No. 1, 08.01.2004, p. 63-66.

Research output: Contribution to journalArticle

Krishnamurthy, M, Gooch, BD & Beal, PA 2004, 'Peptide Quinoline Conjugates: A New Class of RNA-Binding Molecules', Organic Letters, vol. 6, no. 1, pp. 63-66. https://doi.org/10.1021/ol036094+
Krishnamurthy, Malathy ; Gooch, Barry D. ; Beal, Peter A. / Peptide Quinoline Conjugates : A New Class of RNA-Binding Molecules. In: Organic Letters. 2004 ; Vol. 6, No. 1. pp. 63-66.
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