Peptide ligands targeting integrin α3β1 in non-small cell lung cancer

Derick H Lau, Linlang Guo, Ruiwu Liu, Jan Marik, Kit Lam

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Lung cancer is one of the most common cancers and is the leading cause of cancer death. We wish to identify peptide ligands for unique cell surface receptors of non-small lung cancer with the hope of developing these ligands as diagnostic and therapeutic agents. Using the method of 'one-bead one-peptide' combinatorial chemistry, a library of random cyclic octapeptides was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment of lung adenocarcinoma cells employing a 'cell-growth-on-bead' assay. Consensus peptide sequences of cNGXGXXc were identified. These peptides promoted cell adhesion by targeting integrin α3β1 over-expressed in non-small lung cancer cells. These peptide beads can be applied to capture cancer cells in malignant pleural fluid for purpose of diagnosis of lung cancer.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalLung Cancer
Volume52
Issue number3
DOIs
StatePublished - Jun 2006

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Keywords

  • Integrin α3
  • Non-small cell lung cancer
  • One-bead one-peptide combinatorial library
  • Peptide ligand

ASJC Scopus subject areas

  • Oncology

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