Abstract
Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 μg/ml, with a mean drug level in cerebrospinal fluid of 1.3 μg/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 347-348 |
| Number of pages | 2 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 28 |
| Issue number | 2 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis. / Yim, C. W.; Flynn, N. M.; Fitzgerald, Faith T.
In: Antimicrobial Agents and Chemotherapy, Vol. 28, No. 2, 1985, p. 347-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis
AU - Yim, C. W.
AU - Flynn, N. M.
AU - Fitzgerald, Faith T
PY - 1985
Y1 - 1985
N2 - Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 μg/ml, with a mean drug level in cerebrospinal fluid of 1.3 μg/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.
AB - Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 μg/ml, with a mean drug level in cerebrospinal fluid of 1.3 μg/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021861248&partnerID=8YFLogxK
M3 - Article
C2 - 3834836
AN - SCOPUS:0021861248
VL - 28
SP - 347
EP - 348
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 2
ER -