Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis

C. W. Yim, N. M. Flynn, Faith T Fitzgerald

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Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 μg/ml, with a mean drug level in cerebrospinal fluid of 1.3 μg/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.

Original languageEnglish (US)
Pages (from-to)347-348
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Issue number2
StatePublished - 1985


ASJC Scopus subject areas

  • Pharmacology (medical)

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