Abstract
Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 μg/ml, with a mean drug level in cerebrospinal fluid of 1.3 μg/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.
Original language | English (US) |
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Pages (from-to) | 347-348 |
Number of pages | 2 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 28 |
Issue number | 2 |
State | Published - 1985 |
ASJC Scopus subject areas
- Pharmacology (medical)