Pemphigus-like drug reaction after surgical removal of a splenic hemangiosarcoma in a dog

Sung Ah An, Hye Bin Wang, Man Gil Han, In Sung Jung, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A 7-year-old spayed female Shih-tzu dog with 4-month history of anorexia and weight loss was diagnosed with splenic hemangiosarcoma. One week after splenectomy, the dog developed severe, multifocal, coalescing erosive and ulcerative dermatosis with epidermal collarettes and crusts on the dorsal trunk. The dog was prescribed systemic antibiotics comprising cephradine and enrofloxacin postoperatively. Histopathological examination of skin biopsies from haired skin lesions revealed changes consistent with pemphigus foliaceus (PF). Tentative diagnosis for this patient was pemphigus-like drug reaction resulting from cephradine treatment. However, given the dog’s history of hemangiosarcoma, paraneoplastic pemphigus (PNP), a rarely reported cancer-related pemphigus in dogs, was also considered for tentative diagnosis. Significant clinical remission of dermal lesions was achieved with four weeks of prednisolone and mycophenolate mofetil (MMF) treatment. Drugs were gradually tapered and eventually discontinued with concurrent reduction of dermal lesions, and no further recurrence was noted.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalJournal of Veterinary Clinics
Issue number2
StatePublished - Apr 1 2017
Externally publishedYes


  • Canine
  • Drug-related
  • Hemangiosarcoma
  • Paraneoplastic
  • Pemphigus

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Pemphigus-like drug reaction after surgical removal of a splenic hemangiosarcoma in a dog'. Together they form a unique fingerprint.

Cite this