Pemphigus-like drug reaction after surgical removal of a splenic hemangiosarcoma in a dog

Sung Ah An, Hye Bin Wang, Man Gil Han, In Sung Jung, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticle

Abstract

A 7-year-old spayed female Shih-tzu dog with 4-month history of anorexia and weight loss was diagnosed with splenic hemangiosarcoma. One week after splenectomy, the dog developed severe, multifocal, coalescing erosive and ulcerative dermatosis with epidermal collarettes and crusts on the dorsal trunk. The dog was prescribed systemic antibiotics comprising cephradine and enrofloxacin postoperatively. Histopathological examination of skin biopsies from haired skin lesions revealed changes consistent with pemphigus foliaceus (PF). Tentative diagnosis for this patient was pemphigus-like drug reaction resulting from cephradine treatment. However, given the dog’s history of hemangiosarcoma, paraneoplastic pemphigus (PNP), a rarely reported cancer-related pemphigus in dogs, was also considered for tentative diagnosis. Significant clinical remission of dermal lesions was achieved with four weeks of prednisolone and mycophenolate mofetil (MMF) treatment. Drugs were gradually tapered and eventually discontinued with concurrent reduction of dermal lesions, and no further recurrence was noted.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalJournal of Veterinary Clinics
Volume34
Issue number2
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

pemphigus (skin disease)
hemangiosarcoma
Hemangiosarcoma
Pemphigus
Dogs
drugs
Cephradine
dogs
Skin
Pharmaceutical Preparations
lesions (animal)
Mycophenolic Acid
prednisolone
enrofloxacin
remission
skin diseases
Anorexia
Splenectomy
skin lesions
Prednisolone

Keywords

  • Canine
  • Drug-related
  • Hemangiosarcoma
  • Paraneoplastic
  • Pemphigus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pemphigus-like drug reaction after surgical removal of a splenic hemangiosarcoma in a dog. / An, Sung Ah; Wang, Hye Bin; Han, Man Gil; Jung, In Sung; Song, Kun Ho; Seo, Kyoung Won.

In: Journal of Veterinary Clinics, Vol. 34, No. 2, 01.04.2017, p. 103-107.

Research output: Contribution to journalArticle

An, Sung Ah ; Wang, Hye Bin ; Han, Man Gil ; Jung, In Sung ; Song, Kun Ho ; Seo, Kyoung Won. / Pemphigus-like drug reaction after surgical removal of a splenic hemangiosarcoma in a dog. In: Journal of Veterinary Clinics. 2017 ; Vol. 34, No. 2. pp. 103-107.
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