Pediatric super-refractory status epilepticus treated with allopregnanolone

Eileen Broomall, JoAnne E Natale, Michele Grimason, Joshua Goldstein, Craig M. Smith, Celia H Chang, Stephen Kanes, Michael A Rogawski, Mark S. Wainwright

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic c-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with superrefractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children.

Original languageEnglish (US)
Pages (from-to)911-915
Number of pages5
JournalAnnals of Neurology
Volume76
Issue number6
DOIs
StatePublished - Dec 1 2014

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Pregnanolone
Status Epilepticus
Pediatrics
GABA-A Receptors
Benzodiazepines
Aminobutyrates
General Anesthetics
Barbiturates
Neurotransmitter Agents
Seizures
Therapeutics
Recurrence

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)

Cite this

Broomall, E., Natale, J. E., Grimason, M., Goldstein, J., Smith, C. M., Chang, C. H., ... Wainwright, M. S. (2014). Pediatric super-refractory status epilepticus treated with allopregnanolone. Annals of Neurology, 76(6), 911-915. https://doi.org/10.1002/ana.24295

Pediatric super-refractory status epilepticus treated with allopregnanolone. / Broomall, Eileen; Natale, JoAnne E; Grimason, Michele; Goldstein, Joshua; Smith, Craig M.; Chang, Celia H; Kanes, Stephen; Rogawski, Michael A; Wainwright, Mark S.

In: Annals of Neurology, Vol. 76, No. 6, 01.12.2014, p. 911-915.

Research output: Contribution to journalArticle

Broomall, E, Natale, JE, Grimason, M, Goldstein, J, Smith, CM, Chang, CH, Kanes, S, Rogawski, MA & Wainwright, MS 2014, 'Pediatric super-refractory status epilepticus treated with allopregnanolone', Annals of Neurology, vol. 76, no. 6, pp. 911-915. https://doi.org/10.1002/ana.24295
Broomall, Eileen ; Natale, JoAnne E ; Grimason, Michele ; Goldstein, Joshua ; Smith, Craig M. ; Chang, Celia H ; Kanes, Stephen ; Rogawski, Michael A ; Wainwright, Mark S. / Pediatric super-refractory status epilepticus treated with allopregnanolone. In: Annals of Neurology. 2014 ; Vol. 76, No. 6. pp. 911-915.
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