Pediatric midbrain tumors: A benign subgroup of brainstem gliomas

P. L. Robertson, K. M. Muraszko, James A Brunberg, R. A. Axtell, R. C. Dauser, A. T. Turrisi

Research output: Contribution to journalArticle

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Abstract

The presentation, radiographic findings and course of 17 children with MRI-documented intrinsic midbrain lesions are reviewed. The anatomic centers of all the lesions were tectal, peritectal, or tegmental. Lesions centered at the pineal gland were excluded. Signs of increased intracranial pressure from hydrocephalus requiring shunt placement were present in 14 patients. Histopathological diagnosis was confirmed in three tumors; these were low grade astrocytomas and all received focal irradiation, as did one unbiopsied tumor. The remaining 13 patients with no histopathological diagnosis received no therapy other than shunt placement in 11. All but one of the lesions have remained clinically and radiographically stable, with a 4-year progression-free and total survival of 94 and 100 %, respectively. We conclude that mass lesions originating in the upper midbrain are a subset of intrinsic brainstem tumors with a relatively benign course, usually presenting with hydrocephalus after infancy. They may remain stable for considerable periods and may require no further therapy after treatment of hydrocephalus. Surgical biopsy and/or resection can usually be reserved for progressive or atypical lesions which may also require further adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalPediatric Neurosurgery
Volume22
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Brain Stem Neoplasms
Glioma
Brain Stem
Hydrocephalus
Pediatrics
Mesencephalon
Pineal Gland
Astrocytoma
Intracranial Pressure
Therapeutics
Disease-Free Survival
Neoplasms
Biopsy

Keywords

  • Glioma
  • Midbrain
  • Neoplasm
  • Tectal region

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Robertson, P. L., Muraszko, K. M., Brunberg, J. A., Axtell, R. A., Dauser, R. C., & Turrisi, A. T. (1995). Pediatric midbrain tumors: A benign subgroup of brainstem gliomas. Pediatric Neurosurgery, 22(2), 65-73.

Pediatric midbrain tumors : A benign subgroup of brainstem gliomas. / Robertson, P. L.; Muraszko, K. M.; Brunberg, James A; Axtell, R. A.; Dauser, R. C.; Turrisi, A. T.

In: Pediatric Neurosurgery, Vol. 22, No. 2, 1995, p. 65-73.

Research output: Contribution to journalArticle

Robertson, PL, Muraszko, KM, Brunberg, JA, Axtell, RA, Dauser, RC & Turrisi, AT 1995, 'Pediatric midbrain tumors: A benign subgroup of brainstem gliomas', Pediatric Neurosurgery, vol. 22, no. 2, pp. 65-73.
Robertson PL, Muraszko KM, Brunberg JA, Axtell RA, Dauser RC, Turrisi AT. Pediatric midbrain tumors: A benign subgroup of brainstem gliomas. Pediatric Neurosurgery. 1995;22(2):65-73.
Robertson, P. L. ; Muraszko, K. M. ; Brunberg, James A ; Axtell, R. A. ; Dauser, R. C. ; Turrisi, A. T. / Pediatric midbrain tumors : A benign subgroup of brainstem gliomas. In: Pediatric Neurosurgery. 1995 ; Vol. 22, No. 2. pp. 65-73.
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