Patterns of progressive atrophy vary with age in Alzheimer's disease patients

Cassidy M. Fiford, Gerard R. Ridgway, David M. Cash, Marc Modat, Jennifer Nicholas, Emily N. Manning, Ian B. Malone, Geert Jan Biessels, Sebastien Ourselin, Owen T. Carmichael, M. Jorge Cardoso, Josephine Barnes, for the, Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Age is not only the greatest risk factor for Alzheimer's disease (AD) but also a key modifier of disease presentation and progression. Here, we investigate how longitudinal atrophy patterns vary with age in mild cognitive impairment (MCI) and AD. Data comprised serial longitudinal 1.5-T magnetic resonance imaging scans from 153 AD, 339 MCI, and 191 control subjects. Voxel-wise maps of longitudinal volume change were obtained and aligned across subjects. Local volume change was then modeled in terms of diagnostic group and an interaction between group and age, adjusted for total intracranial volume, white-matter hyperintensity volume, and apolipoprotein E genotype. Results were significant at p < 0.05 with family-wise error correction for multiple comparisons. An age-by-group interaction revealed that younger AD patients had significantly faster atrophy rates in the bilateral precuneus, parietal, and superior temporal lobes. These results suggest younger AD patients have predominantly posterior progressive atrophy, unexplained by white-matter hyperintensity, apolipoprotein E, or total intracranial volume. Clinical trials may benefit from adapting outcome measures for patient groups with lower average ages, to capture progressive atrophy in posterior cortices.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
JournalNeurobiology of Aging
Volume63
DOIs
StatePublished - Mar 1 2018
Externally publishedYes

Fingerprint

Atrophy
Alzheimer Disease
Apolipoproteins E
Age Groups
Parietal Lobe
Temporal Lobe
Disease Progression
Genotype
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Clinical Trials
White Matter
Cognitive Dysfunction

Keywords

  • Aging
  • Alzheimer's disease
  • Atrophy
  • Early-onset Alzheimer's disease
  • Hippocampus
  • Late-onset
  • Mild cognitive impairment (MCI)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Fiford, C. M., Ridgway, G. R., Cash, D. M., Modat, M., Nicholas, J., Manning, E. N., ... Alzheimer's Disease Neuroimaging Initiative (2018). Patterns of progressive atrophy vary with age in Alzheimer's disease patients. Neurobiology of Aging, 63, 22-32. https://doi.org/10.1016/j.neurobiolaging.2017.11.002

Patterns of progressive atrophy vary with age in Alzheimer's disease patients. / Fiford, Cassidy M.; Ridgway, Gerard R.; Cash, David M.; Modat, Marc; Nicholas, Jennifer; Manning, Emily N.; Malone, Ian B.; Biessels, Geert Jan; Ourselin, Sebastien; Carmichael, Owen T.; Cardoso, M. Jorge; Barnes, Josephine; for the; Alzheimer's Disease Neuroimaging Initiative.

In: Neurobiology of Aging, Vol. 63, 01.03.2018, p. 22-32.

Research output: Contribution to journalArticle

Fiford, CM, Ridgway, GR, Cash, DM, Modat, M, Nicholas, J, Manning, EN, Malone, IB, Biessels, GJ, Ourselin, S, Carmichael, OT, Cardoso, MJ, Barnes, J, for the & Alzheimer's Disease Neuroimaging Initiative 2018, 'Patterns of progressive atrophy vary with age in Alzheimer's disease patients', Neurobiology of Aging, vol. 63, pp. 22-32. https://doi.org/10.1016/j.neurobiolaging.2017.11.002
Fiford, Cassidy M. ; Ridgway, Gerard R. ; Cash, David M. ; Modat, Marc ; Nicholas, Jennifer ; Manning, Emily N. ; Malone, Ian B. ; Biessels, Geert Jan ; Ourselin, Sebastien ; Carmichael, Owen T. ; Cardoso, M. Jorge ; Barnes, Josephine ; for the ; Alzheimer's Disease Neuroimaging Initiative. / Patterns of progressive atrophy vary with age in Alzheimer's disease patients. In: Neurobiology of Aging. 2018 ; Vol. 63. pp. 22-32.
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