Patterns of neuropsychological deficit in cases of schizophrenia spectrum disorder with and without a family history of psychosis

Frederic J. Sautter, Barbara E McDermott, John Cornwell, F. William Black, Alicia Borges, Janet Johnson, Patrick O'Neill

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This study was designed to identify the types of neuropsychological deficits that are unique to familial and nonfamilial forms of schizophrenia. Seventy-two patients who met Research Diagnostic Criteria for schizophrenia or schizoaffective disorder, mainly schizophrenic, were divided into two groups on the basis of the presence or absence of a family history of psychosis. The two groups were then compared for differences on six neuropsychological parameters as well as for differences in psychotic symptoms. Multivariate analyses indicated that schizophrenic patients with a family history of psychosis showed significantly higher levels of overall neuropsychological deficit and significantly greater deficits on tests of motor-control and abstraction and problem-solving. Factor analyses indicate that schizophrenic patients with a family history of psychosis show a pattern of specific neuropsychological deficits, while schizophrenic patients without a family history show a pattern of more consistent cognitive deficits. The results of this study indicate that recent-onset schizophrenic patients with and without a family history of psychosis show distinctly different patterns of neuropsychological dysfunction. These data suggest that abnormalities in the dorsolateral prefrontal cortex and nonprimary motor areas may be associated with an increased familial risk for psychotic disorder.

Original languageEnglish (US)
Pages (from-to)37-49
Number of pages13
JournalPsychiatry Research
Volume54
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

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Psychotic Disorders
Schizophrenia
Motor Cortex
Prefrontal Cortex
Statistical Factor Analysis
Multivariate Analysis
Research

Keywords

  • cognition
  • Genetics
  • motor control
  • schizoaffective disorder
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Patterns of neuropsychological deficit in cases of schizophrenia spectrum disorder with and without a family history of psychosis. / Sautter, Frederic J.; McDermott, Barbara E; Cornwell, John; William Black, F.; Borges, Alicia; Johnson, Janet; O'Neill, Patrick.

In: Psychiatry Research, Vol. 54, No. 1, 1994, p. 37-49.

Research output: Contribution to journalArticle

Sautter, Frederic J. ; McDermott, Barbara E ; Cornwell, John ; William Black, F. ; Borges, Alicia ; Johnson, Janet ; O'Neill, Patrick. / Patterns of neuropsychological deficit in cases of schizophrenia spectrum disorder with and without a family history of psychosis. In: Psychiatry Research. 1994 ; Vol. 54, No. 1. pp. 37-49.
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