Patterns of cortical neurogenesis

Arnold R. Kriegstein, David R. Castañeda-Castellanos, Stephen C Noctor

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

During cortical development, cell diversity is generated through two classes of divisions. Symmetric divisions produce two daughter cells that are similar, while asymmetric divisions produce daughter cells that are dissimilar. Radial glial cells, long thought to serve as a simple scaffold to support neuronal migration, are now known to be neuronal progenitor cells. Recent data show that radial glial cells generate neurons directly through asymmetric cell division or indirectly by first generating an intermediate progenitor cell (transit amplifying cell) that then divides symmetrically to produce two daughter neurons. The relationship between these division modes is critical for generating neurons in appropriate numbers and assigning them to the correct cortical layers. Additionally, the two division modes occur in different proliferative zones in the embryonic forebrain, suggesting that regulation of division mode may not be cell-autonomous.

Original languageEnglish (US)
Pages (from-to)2-8
Number of pages7
JournalClinical Neuroscience Research
Volume4
Issue number1-2
DOIs
StatePublished - Jul 2004
Externally publishedYes

Keywords

  • Cortical neurogenesis
  • Glia cells
  • Mammalian neocortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Neuropsychology and Physiological Psychology

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