Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection

Basel T. Assaf, Keith G. Mansfield, Susan V. Westmoreland, Amitinder Kaur, Kristie L. Oxford, Don J. Diamond, Peter A Barry

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.

Original languageEnglish (US)
Pages (from-to)6354-6357
Number of pages4
JournalJournal of Virology
Volume86
Issue number11
DOIs
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Assaf, B. T., Mansfield, K. G., Westmoreland, S. V., Kaur, A., Oxford, K. L., Diamond, D. J., & Barry, P. A. (2012). Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection. Journal of Virology, 86(11), 6354-6357. https://doi.org/10.1128/JVI.00607-12