Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers

James A. Waltz, Julie B Schweitzer, James M. Gold, Pradeep K. Kurup, Thomas J. Ross, Betty Jo Salmeron, Emma Jane Rose, Samuel M. McClure, Elliot A. Stein

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

One prevalent theory of learning states that dopamine neurons signal mismatches between expected and actual outcomes, called temporal difference errors (TDEs). Evidence indicates that dopamine system dysfunction is involved in negative symptoms of schizophrenia (SZ), including avolition and anhedonia. As such, we predicted that brain responses to TDEs in dopamine midbrain nuclei and target areas would be abnormal in SZ. A total of 18 clinically stable patients with chronic SZ and 18 controls participated in an fMRI study, which used a passive conditioning task. In the task, the delivery of a small amount of juice followed a light stimulus by exactly 6 s on approximately 75% of 78 total trials, and was further delayed by 4-7 s on the remaining trials. The delayed juice delivery was designed to elicit the two types of TDE signals, associated with the recognition that a reward was omitted at the expected time, and delivered at an unexpected time. Main effects of TDE valence and group differences in the positive-negative TDE contrast (unexpected juice deliveries-juice omissions) were assessed through whole-brain and regions of interest (ROI) analyses. Main effects of TDE valence were observed for the entire sample in the midbrain, left putamen, left cerebellum, and primary gustatory cortex, bilaterally. Whole-brain analyses revealed group differences in the positive-negative TDE contrast in the right putamen and left precentral gyrus, whereas ROI analyses revealed additional group differences in the midbrain, insula, and parietal operculum, on the right, the putamen and cerebellum, on the left, and the frontal operculum, bilaterally. Further, these group differences were generally driven by attenuated responses in patients to positive TDEs (unexpected juice deliveries), whereas responses to negative TDEs (unexpected juice omissions) were largely intact. Patients also showed reductions in responses to juice deliveries on standard trials, and more blunted reinforcer responses in the left putamen corresponded to higher ratings of avolition. These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits.

Original languageEnglish (US)
Pages (from-to)1567-1577
Number of pages11
JournalNeuropsychopharmacology
Volume34
Issue number6
DOIs
StatePublished - May 2009
Externally publishedYes

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Schizophrenia
Putamen
Mesencephalon
Brain
Cerebellum
Dopamine
Anhedonia
Dopaminergic Neurons
Frontal Lobe
Reward
Magnetic Resonance Imaging
Learning
Light

Keywords

  • Basal ganglia
  • Dopamine
  • Reinforcement
  • Schizophrenia
  • Temporal difference error

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers. / Waltz, James A.; Schweitzer, Julie B; Gold, James M.; Kurup, Pradeep K.; Ross, Thomas J.; Jo Salmeron, Betty; Rose, Emma Jane; McClure, Samuel M.; Stein, Elliot A.

In: Neuropsychopharmacology, Vol. 34, No. 6, 05.2009, p. 1567-1577.

Research output: Contribution to journalArticle

Waltz, JA, Schweitzer, JB, Gold, JM, Kurup, PK, Ross, TJ, Jo Salmeron, B, Rose, EJ, McClure, SM & Stein, EA 2009, 'Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers', Neuropsychopharmacology, vol. 34, no. 6, pp. 1567-1577. https://doi.org/10.1038/npp.2008.214
Waltz, James A. ; Schweitzer, Julie B ; Gold, James M. ; Kurup, Pradeep K. ; Ross, Thomas J. ; Jo Salmeron, Betty ; Rose, Emma Jane ; McClure, Samuel M. ; Stein, Elliot A. / Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers. In: Neuropsychopharmacology. 2009 ; Vol. 34, No. 6. pp. 1567-1577.
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