Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability

Gabriella Cerri, Claudio A. Cocchi, Marcella Montagna, Massimo Zuin, Mauro Podda, Paolo Cavallari, Carlo Selmi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Primary biliary cirrhosis (PBC), a female-predominant autoimmune liver disease, is commonly associated with fatigue, a sensation of weariness from physical activity. In healthy subjects, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) increase in amplitude during fatiguing exercise and decrease after the exercise due to post-contraction cortical excitability depression. TMS was utilized herein to investigate if unique cortical excitability changes discriminate women with PBC from healthy controls. Methods: Twenty-two women (11 with PBC and 11 healthy controls) performed a voluntary submaximal tonic contraction of finger flexor muscles until exhaustion; MEPs were recorded before and during exercise as well as 10. min after exercise discontinuation. All subjects completed questionnaires for quality of life and fatigue evaluation. Results: During exercise an increase in MEPs amplitude was observed in all subjects, with no sign of altered peripheral fatigability. Following exercise women with PBC associated with high fatigability showed a significant lack of reduction of MEP size compared to the healthy controls. Conclusions: Women with PBC do not manifest post-exercise depression of cortical excitability. Significance: We suggest that an impairment of neural mechanisms underlying physiological central fatigue could occur in PBC, possibly leading to the pathological fatigability lamented by some patients.

Original languageEnglish (US)
Pages (from-to)1321-1328
Number of pages8
JournalClinical Neurophysiology
Volume121
Issue number8
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Biliary Liver Cirrhosis
Exercise
Motor Evoked Potentials
Fatigue
Transcranial Magnetic Stimulation
Cortical Excitability
Autoimmune Diseases
Fingers
Liver Diseases
Healthy Volunteers
Quality of Life
Depression
Muscles

Keywords

  • Electromyography
  • Muscle fatigue
  • Primary biliary cirrhosis
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Cerri, G., Cocchi, C. A., Montagna, M., Zuin, M., Podda, M., Cavallari, P., & Selmi, C. (2010). Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability. Clinical Neurophysiology, 121(8), 1321-1328. https://doi.org/10.1016/j.clinph.2009.12.040

Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability. / Cerri, Gabriella; Cocchi, Claudio A.; Montagna, Marcella; Zuin, Massimo; Podda, Mauro; Cavallari, Paolo; Selmi, Carlo.

In: Clinical Neurophysiology, Vol. 121, No. 8, 08.2010, p. 1321-1328.

Research output: Contribution to journalArticle

Cerri, G, Cocchi, CA, Montagna, M, Zuin, M, Podda, M, Cavallari, P & Selmi, C 2010, 'Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability', Clinical Neurophysiology, vol. 121, no. 8, pp. 1321-1328. https://doi.org/10.1016/j.clinph.2009.12.040
Cerri, Gabriella ; Cocchi, Claudio A. ; Montagna, Marcella ; Zuin, Massimo ; Podda, Mauro ; Cavallari, Paolo ; Selmi, Carlo. / Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability. In: Clinical Neurophysiology. 2010 ; Vol. 121, No. 8. pp. 1321-1328.
@article{e6e28b81a62543e5a471cd43eae437e0,
title = "Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability",
abstract = "Objective: Primary biliary cirrhosis (PBC), a female-predominant autoimmune liver disease, is commonly associated with fatigue, a sensation of weariness from physical activity. In healthy subjects, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) increase in amplitude during fatiguing exercise and decrease after the exercise due to post-contraction cortical excitability depression. TMS was utilized herein to investigate if unique cortical excitability changes discriminate women with PBC from healthy controls. Methods: Twenty-two women (11 with PBC and 11 healthy controls) performed a voluntary submaximal tonic contraction of finger flexor muscles until exhaustion; MEPs were recorded before and during exercise as well as 10. min after exercise discontinuation. All subjects completed questionnaires for quality of life and fatigue evaluation. Results: During exercise an increase in MEPs amplitude was observed in all subjects, with no sign of altered peripheral fatigability. Following exercise women with PBC associated with high fatigability showed a significant lack of reduction of MEP size compared to the healthy controls. Conclusions: Women with PBC do not manifest post-exercise depression of cortical excitability. Significance: We suggest that an impairment of neural mechanisms underlying physiological central fatigue could occur in PBC, possibly leading to the pathological fatigability lamented by some patients.",
keywords = "Electromyography, Muscle fatigue, Primary biliary cirrhosis, Transcranial magnetic stimulation",
author = "Gabriella Cerri and Cocchi, {Claudio A.} and Marcella Montagna and Massimo Zuin and Mauro Podda and Paolo Cavallari and Carlo Selmi",
year = "2010",
month = "8",
doi = "10.1016/j.clinph.2009.12.040",
language = "English (US)",
volume = "121",
pages = "1321--1328",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "8",

}

TY - JOUR

T1 - Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability

AU - Cerri, Gabriella

AU - Cocchi, Claudio A.

AU - Montagna, Marcella

AU - Zuin, Massimo

AU - Podda, Mauro

AU - Cavallari, Paolo

AU - Selmi, Carlo

PY - 2010/8

Y1 - 2010/8

N2 - Objective: Primary biliary cirrhosis (PBC), a female-predominant autoimmune liver disease, is commonly associated with fatigue, a sensation of weariness from physical activity. In healthy subjects, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) increase in amplitude during fatiguing exercise and decrease after the exercise due to post-contraction cortical excitability depression. TMS was utilized herein to investigate if unique cortical excitability changes discriminate women with PBC from healthy controls. Methods: Twenty-two women (11 with PBC and 11 healthy controls) performed a voluntary submaximal tonic contraction of finger flexor muscles until exhaustion; MEPs were recorded before and during exercise as well as 10. min after exercise discontinuation. All subjects completed questionnaires for quality of life and fatigue evaluation. Results: During exercise an increase in MEPs amplitude was observed in all subjects, with no sign of altered peripheral fatigability. Following exercise women with PBC associated with high fatigability showed a significant lack of reduction of MEP size compared to the healthy controls. Conclusions: Women with PBC do not manifest post-exercise depression of cortical excitability. Significance: We suggest that an impairment of neural mechanisms underlying physiological central fatigue could occur in PBC, possibly leading to the pathological fatigability lamented by some patients.

AB - Objective: Primary biliary cirrhosis (PBC), a female-predominant autoimmune liver disease, is commonly associated with fatigue, a sensation of weariness from physical activity. In healthy subjects, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) increase in amplitude during fatiguing exercise and decrease after the exercise due to post-contraction cortical excitability depression. TMS was utilized herein to investigate if unique cortical excitability changes discriminate women with PBC from healthy controls. Methods: Twenty-two women (11 with PBC and 11 healthy controls) performed a voluntary submaximal tonic contraction of finger flexor muscles until exhaustion; MEPs were recorded before and during exercise as well as 10. min after exercise discontinuation. All subjects completed questionnaires for quality of life and fatigue evaluation. Results: During exercise an increase in MEPs amplitude was observed in all subjects, with no sign of altered peripheral fatigability. Following exercise women with PBC associated with high fatigability showed a significant lack of reduction of MEP size compared to the healthy controls. Conclusions: Women with PBC do not manifest post-exercise depression of cortical excitability. Significance: We suggest that an impairment of neural mechanisms underlying physiological central fatigue could occur in PBC, possibly leading to the pathological fatigability lamented by some patients.

KW - Electromyography

KW - Muscle fatigue

KW - Primary biliary cirrhosis

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=77953880632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953880632&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2009.12.040

DO - 10.1016/j.clinph.2009.12.040

M3 - Article

C2 - 20363183

AN - SCOPUS:77953880632

VL - 121

SP - 1321

EP - 1328

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 8

ER -