Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy

Rishi Rattan, Casey J. Allen, Robert G. Sawyer, Reza Askari, Kaysie L. Banton, Jeffrey A. Claridge, Christine S Cocanour, Raul Coimbra, Charles H. Cook, Joseph Cuschieri, E. Patchen Dellinger, Therese M. Duane, Heather L. Evans, Pamela A. Lipsett, John E. Mazuski, Preston R. Miller, Patrick J. O'Neill, Ori D. Rotstein, Nicholas Namias

Research output: Contribution to journalArticle

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Abstract

Background A recent prospective, multicenter, randomized controlled trial found that 4 days of antibiotics after source control of complicated intra-abdominal infections resulted in similar outcomes when compared with longer duration. We hypothesized that the subset of patients presenting with sepsis have similar outcomes when treated with the shorter course of antibiotics. Study Design Patients from the STOP-IT (Study to Optimize Peritoneal Infection Therapy) trial database meeting criteria for sepsis (ie, temperature <36°C or >38°C and a WBC count <4000 cells/mm3 or >12,000 cells/mm3) were analyzed. Patients had been randomized to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 calendar days of therapy (n = 45), or to receive a fixed short-course of antibiotics for 4 ± 1 calendar days (n = 67). Outcomes included incidence of and time to surgical site infection, recurrent intra-abdominal infection, Clostridium difficile infection, and extra-abdominal infections, as well as hospital days and mortality. Results One hundred and twelve of the 588 patients in the STOP-IT database met criteria for sepsis and were adherent to the protocol. With regard to short- vs long-course therapy, surgical site infection (11.9% vs 8.9%; p = 0.759), recurrent intra-abdominal infection (11.9% vs 13.3%; p = 1.00), extra-abdominal infection (11.9% vs 8.9%; p = 0.759), hospital days (7.4 ± 5.5 days vs 9.0 ± 7.5 days; p = 0.188), days to recurrent intra-abdominal infection (12.5 ± 6.6 days vs 18.0 ± 8.1 days; p = 0.185), days to extra-abdominal infection (12.6 ± 5.8 days vs 17.3 ± 3.9 days; p = 0.194), and mortality (1.5% vs 0%; p = 1.00) were similar. There were no cases of C difficile infection. Days to surgical site infection (6.9 ± 3.5 days vs 21.3 ± 6.1 days; p < 0.001) were fewer in the 4-day therapy group. Conclusions There was no difference in outcomes between short and long-course antimicrobial therapy in patients with complicated intra-abdominal infection presenting with sepsis. Our findings suggest that the presence of systemic illness does not mandate a longer antimicrobial course if source control of complicated intra-abdominal infection is obtained.

Original languageEnglish (US)
Pages (from-to)440-446
Number of pages7
JournalJournal of the American College of Surgeons
Volume222
Issue number4
DOIs
StatePublished - Apr 1 2016

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Intraabdominal Infections
Sepsis
Surgical Wound Infection
Infection
Anti-Bacterial Agents
Therapeutics
Databases
Clostridium Infections
Clostridium difficile
Ileus
Leukocytosis
Group Psychotherapy
Hospital Mortality
Fever
Randomized Controlled Trials
Temperature
Mortality
Incidence

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

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Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy. / Rattan, Rishi; Allen, Casey J.; Sawyer, Robert G.; Askari, Reza; Banton, Kaysie L.; Claridge, Jeffrey A.; Cocanour, Christine S; Coimbra, Raul; Cook, Charles H.; Cuschieri, Joseph; Dellinger, E. Patchen; Duane, Therese M.; Evans, Heather L.; Lipsett, Pamela A.; Mazuski, John E.; Miller, Preston R.; O'Neill, Patrick J.; Rotstein, Ori D.; Namias, Nicholas.

In: Journal of the American College of Surgeons, Vol. 222, No. 4, 01.04.2016, p. 440-446.

Research output: Contribution to journalArticle

Rattan, R, Allen, CJ, Sawyer, RG, Askari, R, Banton, KL, Claridge, JA, Cocanour, CS, Coimbra, R, Cook, CH, Cuschieri, J, Dellinger, EP, Duane, TM, Evans, HL, Lipsett, PA, Mazuski, JE, Miller, PR, O'Neill, PJ, Rotstein, OD & Namias, N 2016, 'Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy', Journal of the American College of Surgeons, vol. 222, no. 4, pp. 440-446. https://doi.org/10.1016/j.jamcollsurg.2015.12.050
Rattan, Rishi ; Allen, Casey J. ; Sawyer, Robert G. ; Askari, Reza ; Banton, Kaysie L. ; Claridge, Jeffrey A. ; Cocanour, Christine S ; Coimbra, Raul ; Cook, Charles H. ; Cuschieri, Joseph ; Dellinger, E. Patchen ; Duane, Therese M. ; Evans, Heather L. ; Lipsett, Pamela A. ; Mazuski, John E. ; Miller, Preston R. ; O'Neill, Patrick J. ; Rotstein, Ori D. ; Namias, Nicholas. / Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy. In: Journal of the American College of Surgeons. 2016 ; Vol. 222, No. 4. pp. 440-446.
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abstract = "Background A recent prospective, multicenter, randomized controlled trial found that 4 days of antibiotics after source control of complicated intra-abdominal infections resulted in similar outcomes when compared with longer duration. We hypothesized that the subset of patients presenting with sepsis have similar outcomes when treated with the shorter course of antibiotics. Study Design Patients from the STOP-IT (Study to Optimize Peritoneal Infection Therapy) trial database meeting criteria for sepsis (ie, temperature <36°C or >38°C and a WBC count <4000 cells/mm3 or >12,000 cells/mm3) were analyzed. Patients had been randomized to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 calendar days of therapy (n = 45), or to receive a fixed short-course of antibiotics for 4 ± 1 calendar days (n = 67). Outcomes included incidence of and time to surgical site infection, recurrent intra-abdominal infection, Clostridium difficile infection, and extra-abdominal infections, as well as hospital days and mortality. Results One hundred and twelve of the 588 patients in the STOP-IT database met criteria for sepsis and were adherent to the protocol. With regard to short- vs long-course therapy, surgical site infection (11.9{\%} vs 8.9{\%}; p = 0.759), recurrent intra-abdominal infection (11.9{\%} vs 13.3{\%}; p = 1.00), extra-abdominal infection (11.9{\%} vs 8.9{\%}; p = 0.759), hospital days (7.4 ± 5.5 days vs 9.0 ± 7.5 days; p = 0.188), days to recurrent intra-abdominal infection (12.5 ± 6.6 days vs 18.0 ± 8.1 days; p = 0.185), days to extra-abdominal infection (12.6 ± 5.8 days vs 17.3 ± 3.9 days; p = 0.194), and mortality (1.5{\%} vs 0{\%}; p = 1.00) were similar. There were no cases of C difficile infection. Days to surgical site infection (6.9 ± 3.5 days vs 21.3 ± 6.1 days; p < 0.001) were fewer in the 4-day therapy group. Conclusions There was no difference in outcomes between short and long-course antimicrobial therapy in patients with complicated intra-abdominal infection presenting with sepsis. Our findings suggest that the presence of systemic illness does not mandate a longer antimicrobial course if source control of complicated intra-abdominal infection is obtained.",
author = "Rishi Rattan and Allen, {Casey J.} and Sawyer, {Robert G.} and Reza Askari and Banton, {Kaysie L.} and Claridge, {Jeffrey A.} and Cocanour, {Christine S} and Raul Coimbra and Cook, {Charles H.} and Joseph Cuschieri and Dellinger, {E. Patchen} and Duane, {Therese M.} and Evans, {Heather L.} and Lipsett, {Pamela A.} and Mazuski, {John E.} and Miller, {Preston R.} and O'Neill, {Patrick J.} and Rotstein, {Ori D.} and Nicholas Namias",
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T1 - Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy

AU - Rattan, Rishi

AU - Allen, Casey J.

AU - Sawyer, Robert G.

AU - Askari, Reza

AU - Banton, Kaysie L.

AU - Claridge, Jeffrey A.

AU - Cocanour, Christine S

AU - Coimbra, Raul

AU - Cook, Charles H.

AU - Cuschieri, Joseph

AU - Dellinger, E. Patchen

AU - Duane, Therese M.

AU - Evans, Heather L.

AU - Lipsett, Pamela A.

AU - Mazuski, John E.

AU - Miller, Preston R.

AU - O'Neill, Patrick J.

AU - Rotstein, Ori D.

AU - Namias, Nicholas

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background A recent prospective, multicenter, randomized controlled trial found that 4 days of antibiotics after source control of complicated intra-abdominal infections resulted in similar outcomes when compared with longer duration. We hypothesized that the subset of patients presenting with sepsis have similar outcomes when treated with the shorter course of antibiotics. Study Design Patients from the STOP-IT (Study to Optimize Peritoneal Infection Therapy) trial database meeting criteria for sepsis (ie, temperature <36°C or >38°C and a WBC count <4000 cells/mm3 or >12,000 cells/mm3) were analyzed. Patients had been randomized to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 calendar days of therapy (n = 45), or to receive a fixed short-course of antibiotics for 4 ± 1 calendar days (n = 67). Outcomes included incidence of and time to surgical site infection, recurrent intra-abdominal infection, Clostridium difficile infection, and extra-abdominal infections, as well as hospital days and mortality. Results One hundred and twelve of the 588 patients in the STOP-IT database met criteria for sepsis and were adherent to the protocol. With regard to short- vs long-course therapy, surgical site infection (11.9% vs 8.9%; p = 0.759), recurrent intra-abdominal infection (11.9% vs 13.3%; p = 1.00), extra-abdominal infection (11.9% vs 8.9%; p = 0.759), hospital days (7.4 ± 5.5 days vs 9.0 ± 7.5 days; p = 0.188), days to recurrent intra-abdominal infection (12.5 ± 6.6 days vs 18.0 ± 8.1 days; p = 0.185), days to extra-abdominal infection (12.6 ± 5.8 days vs 17.3 ± 3.9 days; p = 0.194), and mortality (1.5% vs 0%; p = 1.00) were similar. There were no cases of C difficile infection. Days to surgical site infection (6.9 ± 3.5 days vs 21.3 ± 6.1 days; p < 0.001) were fewer in the 4-day therapy group. Conclusions There was no difference in outcomes between short and long-course antimicrobial therapy in patients with complicated intra-abdominal infection presenting with sepsis. Our findings suggest that the presence of systemic illness does not mandate a longer antimicrobial course if source control of complicated intra-abdominal infection is obtained.

AB - Background A recent prospective, multicenter, randomized controlled trial found that 4 days of antibiotics after source control of complicated intra-abdominal infections resulted in similar outcomes when compared with longer duration. We hypothesized that the subset of patients presenting with sepsis have similar outcomes when treated with the shorter course of antibiotics. Study Design Patients from the STOP-IT (Study to Optimize Peritoneal Infection Therapy) trial database meeting criteria for sepsis (ie, temperature <36°C or >38°C and a WBC count <4000 cells/mm3 or >12,000 cells/mm3) were analyzed. Patients had been randomized to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 calendar days of therapy (n = 45), or to receive a fixed short-course of antibiotics for 4 ± 1 calendar days (n = 67). Outcomes included incidence of and time to surgical site infection, recurrent intra-abdominal infection, Clostridium difficile infection, and extra-abdominal infections, as well as hospital days and mortality. Results One hundred and twelve of the 588 patients in the STOP-IT database met criteria for sepsis and were adherent to the protocol. With regard to short- vs long-course therapy, surgical site infection (11.9% vs 8.9%; p = 0.759), recurrent intra-abdominal infection (11.9% vs 13.3%; p = 1.00), extra-abdominal infection (11.9% vs 8.9%; p = 0.759), hospital days (7.4 ± 5.5 days vs 9.0 ± 7.5 days; p = 0.188), days to recurrent intra-abdominal infection (12.5 ± 6.6 days vs 18.0 ± 8.1 days; p = 0.185), days to extra-abdominal infection (12.6 ± 5.8 days vs 17.3 ± 3.9 days; p = 0.194), and mortality (1.5% vs 0%; p = 1.00) were similar. There were no cases of C difficile infection. Days to surgical site infection (6.9 ± 3.5 days vs 21.3 ± 6.1 days; p < 0.001) were fewer in the 4-day therapy group. Conclusions There was no difference in outcomes between short and long-course antimicrobial therapy in patients with complicated intra-abdominal infection presenting with sepsis. Our findings suggest that the presence of systemic illness does not mandate a longer antimicrobial course if source control of complicated intra-abdominal infection is obtained.

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