Pathophysiology of Cortical Synapses and Circuits

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter focuses on the cellular features of the epileptic brain that may be key to an understanding of mechanisms underlying the pathophysiological discharge. The major issues are reviewed in historical context to show how our views have evolved from electrophysiological analyses of epileptogenic cortical tissues. Intrinsic cellular and synaptic contributions to the abnormal activities are examined, and illustrations are drawn from studies of chronic animal models of the epilepsies.

Original languageEnglish (US)
Title of host publicationThe Cortical Neuron
PublisherOxford University Press
ISBN (Print)9780199847464, 9780195083309
StatePublished - Mar 22 2012
Externally publishedYes


  • Cortical tissues
  • Epilepsy
  • Epileptic brain
  • Pathophysiology

ASJC Scopus subject areas

  • Neuroscience(all)


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