Abstract
Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of these diseases continue to be an area of investigation. Herein, we discuss several of the potential environmental triggers that may induce patients to develop immunobullous diseases including medications, viral infections, UV exposure or other radiation injury and dietary factors. In addition, the potential genetic and immunologic mechanisms contributing to the pathogenesis of pemphigus and pemphigoid will be reviewed. The multifactorial nature of these diseases contributes to their complexity and highlights the importance of a detailed personal and family history when caring for these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 262-267 |
| Number of pages | 6 |
| Journal | Indian Journal of Dermatology |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1 2017 |
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Keywords
- Autoimmune blistering diseases
- desmoglein
- pemphigoid
- pemphigus
ASJC Scopus subject areas
- Dermatology
Cite this
Pathophysiology of autoimmune bullous diseases : Nature versus nurture. / Patel, Forum; Wilken, Reason; Patel, Falin B.; Sultani, Hawa; Bustos, Itzel; Duong, Christopher; Zone, John J.; Raychaudhuri, Siba P; Maverakis, Emanual Michael.
In: Indian Journal of Dermatology, Vol. 62, No. 3, 01.05.2017, p. 262-267.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology of autoimmune bullous diseases
T2 - Nature versus nurture
AU - Patel, Forum
AU - Wilken, Reason
AU - Patel, Falin B.
AU - Sultani, Hawa
AU - Bustos, Itzel
AU - Duong, Christopher
AU - Zone, John J.
AU - Raychaudhuri, Siba P
AU - Maverakis, Emanual Michael
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of these diseases continue to be an area of investigation. Herein, we discuss several of the potential environmental triggers that may induce patients to develop immunobullous diseases including medications, viral infections, UV exposure or other radiation injury and dietary factors. In addition, the potential genetic and immunologic mechanisms contributing to the pathogenesis of pemphigus and pemphigoid will be reviewed. The multifactorial nature of these diseases contributes to their complexity and highlights the importance of a detailed personal and family history when caring for these patients.
AB - Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of these diseases continue to be an area of investigation. Herein, we discuss several of the potential environmental triggers that may induce patients to develop immunobullous diseases including medications, viral infections, UV exposure or other radiation injury and dietary factors. In addition, the potential genetic and immunologic mechanisms contributing to the pathogenesis of pemphigus and pemphigoid will be reviewed. The multifactorial nature of these diseases contributes to their complexity and highlights the importance of a detailed personal and family history when caring for these patients.
KW - Autoimmune blistering diseases
KW - desmoglein
KW - pemphigoid
KW - pemphigus
UR - http://www.scopus.com/inward/record.url?scp=85019747270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019747270&partnerID=8YFLogxK
U2 - 10.4103/0019-5154.159620
DO - 10.4103/0019-5154.159620
M3 - Article
AN - SCOPUS:85019747270
VL - 62
SP - 262
EP - 267
JO - Indian Journal of Dermatology
JF - Indian Journal of Dermatology
SN - 0019-5154
IS - 3
ER -