Pathology of bartonella endocarditis in six dogs

Patricia Pesavento, Bruno B Chomel, R. W. Kasten, K. A. Mcdonald, Frederick C Mohr

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In a 5-year retrospective study of dogs presenting to the Veterinary Medical Teaching Hospital at the University of California, Davis, there were 31 histologic diagnoses of valvular endocarditis. By polymerase chain reaction (PCR) amplification of embedded valvular tissue, Bartonella organisms were exclusively associated with 6 out of 31 cases (19%). Confirmed Bartonella cases involved the aortic valve alone (five out of six) or in combination with the mitral valve (one of six). Microscopic features of Bartonella endocarditis were compared with valves from non-Bartonella endocarditis and with valvular change unrelated to infectious agents (endocardiosis). Features of Bartonella endocarditis included a combination of fibrosis, mineralization, endothelial proliferation, and neovascularization with variable inflammation. None of these features is specific; however, the combination is distinct both from endocarditis caused by culturable bacteria and from endocardiosis. Ultrastructural analyses revealed both extracellular and intraendothelial bacteria. Clinical history, serology, and PCR are currently necessary to establish an etiologic diagnosis of Bartonella endocarditis.

Original languageEnglish (US)
Pages (from-to)370-373
Number of pages4
JournalVeterinary Pathology
Volume42
Issue number3
DOIs
StatePublished - May 2005

Fingerprint

Bartonella
endocarditis
Endocarditis
Dogs
Pathology
dogs
polymerase chain reaction
Bacteria
Polymerase Chain Reaction
bacteria
Serology
angiogenesis
fibrosis
Aortic Valve
Mitral Valve
retrospective studies
Teaching Hospitals
mineralization
Fibrosis
Retrospective Studies

Keywords

  • Bacteria
  • Bartonella
  • Dogs
  • Endocarditis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pathology of bartonella endocarditis in six dogs. / Pesavento, Patricia; Chomel, Bruno B; Kasten, R. W.; Mcdonald, K. A.; Mohr, Frederick C.

In: Veterinary Pathology, Vol. 42, No. 3, 05.2005, p. 370-373.

Research output: Contribution to journalArticle

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