Pathology and proposed pathophysiology of diclofenac poisoning in free-living and experimentally exposed oriental white-backed vultures (Gyps Bengalensis)

Carol Uphoff Meteyer, Bruce A. Rideout, Martin Gilbert, H L Shivaprasad, J. Lindsay Oaks

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Oriental white-backed vultures (Gyps bengalensis; OWBVs) died of renal failure when they ingested diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), in tissues of domestic livestock. Acute necrosis of proximal convoluted tubules in these vultures was severe. Glomeruli, distal convoluted tubules, and collecting tubules were relatively spared in the vultures that had early lesions. In most vultures, however, lesions became extensive with large urate aggregates obscuring renal architecture. Inflammation was minimal. Extensive urate precipitation on the surface and within organ parenchyma (visceral gout) was consistently found in vultures with renal failure. Very little is known about the physiologic effect of NSAIDs in birds. Research in mammals has shown that diclofenac inhibits formation of prostaglandins. We propose that the mechanism by which diclofenac induces renal failure in the OWBV is through the inhibition of the modulating effect of prostaglandin on angiotensin II-mediated adrenergic stimulation. Renal portal valves open in response to adrenergic stimulation, redirecting portal blood to the caudal vena cava and bypassing the kidney. If diclofenac removes a modulating effect of prostaglandins on the renal portal valves, indiscriminant activation of these valves would redirect the primary nutrient blood supply away from the renal cortex. Resulting ischemic necrosis of the cortical proximal convoluted tubules would be consistent with our histologic findings in these OWBVs.

Original languageEnglish (US)
Pages (from-to)707-716
Number of pages10
JournalJournal of Wildlife Diseases
Volume41
Issue number4
StatePublished - Oct 2005

Fingerprint

Diclofenac
pathology
pathophysiology
poisoning
Poisoning
kidneys
Pathology
Kidney
lesion
renal failure
prostaglandins
Prostaglandins
Renal Insufficiency
blood
proximal tubules
nonsteroidal anti-inflammatory agents
Uric Acid
lesions (animal)
Adrenergic Agents
necrosis

Keywords

  • Diclofenac
  • Gyps bengalensis
  • Nonsteroidal anti-inflammatory drugs
  • Oriental white-backed vulture
  • Pharmaceutical residues
  • Renal portal system
  • Renal tubule necrosis
  • Visceral gout

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pathology and proposed pathophysiology of diclofenac poisoning in free-living and experimentally exposed oriental white-backed vultures (Gyps Bengalensis). / Meteyer, Carol Uphoff; Rideout, Bruce A.; Gilbert, Martin; Shivaprasad, H L; Oaks, J. Lindsay.

In: Journal of Wildlife Diseases, Vol. 41, No. 4, 10.2005, p. 707-716.

Research output: Contribution to journalArticle

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