Pathological grading system for hippocampal sclerosis: Correlation with magnetic resonance imaging-based volume measurements of the hippocampus

Craig Watson, Surl L. Nielsen, Cully Cobb, Robert Burgerman, Bill Williamson

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We studied 20 consecutive patients with medically intractable temporal lobe epilepsy (TLE) using volumetric magnetic resonance imaging (MRI) measurements of the hippocampus. We calculate a 'preoperative hippocampal ratio' to determine the degree of hippocampal atrophy on the epileptogenic side as compared with that on the nonepileptogenic or normal side. We then correlated the degree of hippocampal atrophy with the severity of hippocampal sclerosis as determined by a practical, semiquantitative grading system adapted from the schema proposed by Wyler et al. (6). The study confirmed the usefulness of our six-tiered grading system in detecting and characterizing the severity of hippocampal sclerosis. Eighteen of our patients had identifiable hippocampal sclerosis, ranging from minimal (grade I) to severe (grade V). The degree of hippocampal atrophy as measured with preoperative volumetric MRI correlated well with the severity of hippocampal sclerosis as determined by the pathological grading system. These two techniques should aid in the diagnosis, treatment, and research assessment of patients with intractable TLE.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalJournal of Epilepsy
Volume9
Issue number1
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Hippocampal sclerosis
  • Pathology
  • Temporal lobe epilepsy
  • Temporal lobectomy
  • Volumetric magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Pathological grading system for hippocampal sclerosis: Correlation with magnetic resonance imaging-based volume measurements of the hippocampus'. Together they form a unique fingerprint.

  • Cite this