Pathogenicity and transmission of virulent Newcastle disease virus from the 2018–2019 California outbreak and related viruses in young and adult chickens

Kiril M. Dimitrov, Helena L. Ferreira, Mary J. Pantin-Jackwood, Tonya L. Taylor, Iryna V. Goraichuk, Beate Crossley, Mary Lea Killian, Nichole Hines Bergeson, Mia Kim Torchetti, Claudio L. Afonso, David L. Suarez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In May of 2018, virulent Newcastle disease virus was detected in sick, backyard, exhibition chickens in southern California. Since, the virus has affected 401 backyard and four commercial flocks, and one live bird market in California, and one backyard flock in Utah. The pathogenesis and transmission potential of this virus, along with two genetically related and widely studied viruses, chicken/California/2002 and chicken/Belize/2008, were evaluated in both 3-week- and 62-week-old chickens given a low, medium, or high challenge dose. All three viruses were highly virulent causing clinical signs, killing all the chickens in the medium and high dose groups, and efficiently transmitting to contacts. The three viruses also replicated in the reproductive tract of the adult hens. Virus shedding for all viruses was detected 24 hours after challenge, peaking with high titers at day 4 post challenge. Although not genetically identical, the studied isolates were shown to be phenotypically very similar, which allows the utilization of the available literature in the control of the current outbreak.

Original languageEnglish (US)
Pages (from-to)203-218
Number of pages16
JournalVirology
Volume531
DOIs
StatePublished - May 1 2019

Fingerprint

Newcastle disease virus
Disease Outbreaks
Virulence
Young Adult
Chickens
Viruses
California Encephalitis Viruses
Belize
Virus Shedding
Birds

Keywords

  • Avian avulavirus1
  • Avian paramyxovirus 1
  • California
  • Immunohistochemistry
  • Lesions
  • Newcastle disease virus
  • Pathogenesis
  • Shedding
  • Transmission

ASJC Scopus subject areas

  • Virology

Cite this

Pathogenicity and transmission of virulent Newcastle disease virus from the 2018–2019 California outbreak and related viruses in young and adult chickens. / Dimitrov, Kiril M.; Ferreira, Helena L.; Pantin-Jackwood, Mary J.; Taylor, Tonya L.; Goraichuk, Iryna V.; Crossley, Beate; Killian, Mary Lea; Bergeson, Nichole Hines; Torchetti, Mia Kim; Afonso, Claudio L.; Suarez, David L.

In: Virology, Vol. 531, 01.05.2019, p. 203-218.

Research output: Contribution to journalArticle

Dimitrov, KM, Ferreira, HL, Pantin-Jackwood, MJ, Taylor, TL, Goraichuk, IV, Crossley, B, Killian, ML, Bergeson, NH, Torchetti, MK, Afonso, CL & Suarez, DL 2019, 'Pathogenicity and transmission of virulent Newcastle disease virus from the 2018–2019 California outbreak and related viruses in young and adult chickens', Virology, vol. 531, pp. 203-218. https://doi.org/10.1016/j.virol.2019.03.010
Dimitrov, Kiril M. ; Ferreira, Helena L. ; Pantin-Jackwood, Mary J. ; Taylor, Tonya L. ; Goraichuk, Iryna V. ; Crossley, Beate ; Killian, Mary Lea ; Bergeson, Nichole Hines ; Torchetti, Mia Kim ; Afonso, Claudio L. ; Suarez, David L. / Pathogenicity and transmission of virulent Newcastle disease virus from the 2018–2019 California outbreak and related viruses in young and adult chickens. In: Virology. 2019 ; Vol. 531. pp. 203-218.
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