Pathogenic conversion of live attenuated simian immunodeficiency virus vaccines is associated with expression of truncated nef

Earl T. Sawai, M. Sabry Hamza, Michael Ye, Karen E S Shaw, Paul A Luciw

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Rhesus macaques infected with simian immunodeficiency virus (SIV) containing either a large nef deletion (SIVmac239Δ152]nef) or interleukin-2 in place of nef developed high virus loads and progressed to simian AIDS. Viruses recovered from both juvenile and neonatal macaques with disease produced a novel truncated Nef protein, tNef. Viruses recovered from juvenile macaques infected with serially passaged virus expressing tNef exhibited a pathogenic phenotype. These findings demonstrated strong selective pressure to restore expression of a truncated Nef protein, and this reversion was linked to increased pathogenic potential in live attenuated SIV vaccines.

Original languageEnglish (US)
Pages (from-to)2038-2045
Number of pages8
JournalJournal of Virology
Volume74
Issue number4
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Immunology

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