Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus.

D. H. Maul, N. W. Lerche, K. G. Osborn, P. A. Marx, C. Zaiss, A. Spinner, J. D. Kluge, M. R. MacKenzie, L. J. Lowenstine, M. L. Bryant

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Type D retrovirus was isolated from rhesus macaques with simian acquired immunodeficiency syndrome (SAIDS) and transmitted to healthy rhesus macaques with tissue culture medium containing the virus. The clinical, immunologic, and lymph node morphologic changes were observed in 9 rhesus macaques for 52 weeks after inoculation. A spectrum of clinical signs developed including early death, persistent SAIDS, and apparent remission. Animals that died or developed persistent SAIDS had characteristic lymphoid depletion, persistently depressed peripheral blood mononuclear cell (PBMC) mitogenic response, and decreased serum immunoglobulins. The SAIDS retrovirus (SRV) was recovered from PBMC of 8 of the animals after inoculation. Virus could not be recovered from PBMC of one animal in remission, but this animal developed serum-neutralizing antibodies to SRV after inoculation. Seven of the animals seroconverted to SRV after inoculation, all 9 were seronegative for human T-lymphotropic virus-III, and 5 animals tested were seronegative to human T-lymphotropic virus-I. These findings support the etiologic role of the type D retrovirus in SAIDS and further define the pathogenesis of this disease.

Original languageEnglish (US)
Pages (from-to)863-868
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume47
Issue number4
StatePublished - Apr 1986

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus.'. Together they form a unique fingerprint.

  • Cite this

    Maul, D. H., Lerche, N. W., Osborn, K. G., Marx, P. A., Zaiss, C., Spinner, A., Kluge, J. D., MacKenzie, M. R., Lowenstine, L. J., & Bryant, M. L. (1986). Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus. American Journal of Veterinary Research, 47(4), 863-868.