Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus.

D. H. Maul, N. W. Lerche, K. G. Osborn, P. A. Marx, C. Zaiss, A. Spinner, J. D. Kluge, M. R. MacKenzie, Linda J Lowenstine, M. L. Bryant

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Abstract

Type D retrovirus was isolated from rhesus macaques with simian acquired immunodeficiency syndrome (SAIDS) and transmitted to healthy rhesus macaques with tissue culture medium containing the virus. The clinical, immunologic, and lymph node morphologic changes were observed in 9 rhesus macaques for 52 weeks after inoculation. A spectrum of clinical signs developed including early death, persistent SAIDS, and apparent remission. Animals that died or developed persistent SAIDS had characteristic lymphoid depletion, persistently depressed peripheral blood mononuclear cell (PBMC) mitogenic response, and decreased serum immunoglobulins. The SAIDS retrovirus (SRV) was recovered from PBMC of 8 of the animals after inoculation. Virus could not be recovered from PBMC of one animal in remission, but this animal developed serum-neutralizing antibodies to SRV after inoculation. Seven of the animals seroconverted to SRV after inoculation, all 9 were seronegative for human T-lymphotropic virus-III, and 5 animals tested were seronegative to human T-lymphotropic virus-I. These findings support the etiologic role of the type D retrovirus in SAIDS and further define the pathogenesis of this disease.

Original languageEnglish (US)
Pages (from-to)863-868
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume47
Issue number4
StatePublished - Apr 1986

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Simian Acquired Immunodeficiency Syndrome
Retroviridae
Betaretrovirus
acquired immunodeficiency syndrome
Macaca mulatta
pathogenesis
mononuclear leukocytes
viruses
animals
Viruses
remission
Blood Cells
neutralizing antibodies
immunoglobulins
lymph nodes
tissue culture
Neutralizing Antibodies
Serum
culture media
Culture Media

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Maul, D. H., Lerche, N. W., Osborn, K. G., Marx, P. A., Zaiss, C., Spinner, A., ... Bryant, M. L. (1986). Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus. American Journal of Veterinary Research, 47(4), 863-868.

Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus. / Maul, D. H.; Lerche, N. W.; Osborn, K. G.; Marx, P. A.; Zaiss, C.; Spinner, A.; Kluge, J. D.; MacKenzie, M. R.; Lowenstine, Linda J; Bryant, M. L.

In: American Journal of Veterinary Research, Vol. 47, No. 4, 04.1986, p. 863-868.

Research output: Contribution to journalArticle

Maul, DH, Lerche, NW, Osborn, KG, Marx, PA, Zaiss, C, Spinner, A, Kluge, JD, MacKenzie, MR, Lowenstine, LJ & Bryant, ML 1986, 'Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus.', American Journal of Veterinary Research, vol. 47, no. 4, pp. 863-868.
Maul, D. H. ; Lerche, N. W. ; Osborn, K. G. ; Marx, P. A. ; Zaiss, C. ; Spinner, A. ; Kluge, J. D. ; MacKenzie, M. R. ; Lowenstine, Linda J ; Bryant, M. L. / Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus. In: American Journal of Veterinary Research. 1986 ; Vol. 47, No. 4. pp. 863-868.
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