Pathogenesis of Salmonella-induced enteritis

R. L. Santos, Renee M Tsolis, Andreas J Baumler, L. G. Adams

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Infections with Salmonella serotypes are a major cause of food-borne diseases worldwide. Animal models other than the mouse have been employed for the study of nontyphoidal Salmonella infections because the murine model is not suitable for the study of Salmonella-induced diarrhea. The microbe has developed mechanisms to exploit the host cell machinery to its own purpose. Bacterial proteins delivered directly into the host cell cytosol cause cytoskeletal changes and interfere with host cell signaling pathways, which ultimately enhance disease manifestation. Recently, marked advances have been made in our understanding of the molecular interactions between Salmonella serotypes and their hosts. Here, we discuss the molecular basis of the pathogenesis of Salmonella-induced enteritis.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalBrazilian Journal of Medical and Biological Research
Volume36
Issue number1
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Diarrhea
  • Enteritis
  • Salmonella typhimurium
  • Salmonellosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

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