Abstract
Gut-associated lymphoid tissue (GALT) is an important site for early HIV replication and severe CD4+ T-cell depletion. Initiation of highly active antiretroviral therapy leads to incomplete suppression of viral replication and substantially delayed and only partial restoration of CD4+ T cells in GALT compared with peripheral blood. Persistent viral replication in GALT leads to replenishment and maintenance of viral reservoirs. Increased levels of inflammation, immune activation, and decreased levels of mucosal repair and regeneration contribute to enteropathy. Assessment of gut mucosal immune system will provide better insights into the efficacy of highly active antiretroviral therapy in immune restoration and suppression of viral reservoirs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10-15 |
| Number of pages | 6 |
| Journal | Current HIV/AIDS Reports |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2007 |
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ASJC Scopus subject areas
- Virology
- Infectious Diseases
Cite this
Pathogenesis of HIV in the gastrointestinal tract. / Dandekar, Satya.
In: Current HIV/AIDS Reports, Vol. 4, No. 1, 02.2007, p. 10-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathogenesis of HIV in the gastrointestinal tract
AU - Dandekar, Satya
PY - 2007/2
Y1 - 2007/2
N2 - Gut-associated lymphoid tissue (GALT) is an important site for early HIV replication and severe CD4+ T-cell depletion. Initiation of highly active antiretroviral therapy leads to incomplete suppression of viral replication and substantially delayed and only partial restoration of CD4+ T cells in GALT compared with peripheral blood. Persistent viral replication in GALT leads to replenishment and maintenance of viral reservoirs. Increased levels of inflammation, immune activation, and decreased levels of mucosal repair and regeneration contribute to enteropathy. Assessment of gut mucosal immune system will provide better insights into the efficacy of highly active antiretroviral therapy in immune restoration and suppression of viral reservoirs.
AB - Gut-associated lymphoid tissue (GALT) is an important site for early HIV replication and severe CD4+ T-cell depletion. Initiation of highly active antiretroviral therapy leads to incomplete suppression of viral replication and substantially delayed and only partial restoration of CD4+ T cells in GALT compared with peripheral blood. Persistent viral replication in GALT leads to replenishment and maintenance of viral reservoirs. Increased levels of inflammation, immune activation, and decreased levels of mucosal repair and regeneration contribute to enteropathy. Assessment of gut mucosal immune system will provide better insights into the efficacy of highly active antiretroviral therapy in immune restoration and suppression of viral reservoirs.
UR - http://www.scopus.com/inward/record.url?scp=34147108762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147108762&partnerID=8YFLogxK
U2 - 10.1007/s11904-007-0002-0
DO - 10.1007/s11904-007-0002-0
M3 - Article
C2 - 17338855
AN - SCOPUS:34147108762
VL - 4
SP - 10
EP - 15
JO - Current HIV/AIDS Reports
JF - Current HIV/AIDS Reports
SN - 1548-3568
IS - 1
ER -