Pathogenesis of HIV in the gastrointestinal tract

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Gut-associated lymphoid tissue (GALT) is an important site for early HIV replication and severe CD4+ T-cell depletion. Initiation of highly active antiretroviral therapy leads to incomplete suppression of viral replication and substantially delayed and only partial restoration of CD4+ T cells in GALT compared with peripheral blood. Persistent viral replication in GALT leads to replenishment and maintenance of viral reservoirs. Increased levels of inflammation, immune activation, and decreased levels of mucosal repair and regeneration contribute to enteropathy. Assessment of gut mucosal immune system will provide better insights into the efficacy of highly active antiretroviral therapy in immune restoration and suppression of viral reservoirs.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalCurrent HIV/AIDS Reports
Volume4
Issue number1
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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